Iron Metabolism Disorders
Conditions
Brief summary
The aim of this study is to measure the variations of serum and urinary hepcidin levels following a single intravenous injection of erythropoietin in healthy volunteers. Hepcidin is a major regulator of iron homeostasis. It acts by binding on ferroportin, and limits cellular efflux of iron through enterocytes and macrophages. Anemia and hypoxia are known to modulate hepcidin synthesis. In these situations, erythropoietin synthesis is increased, so it can be postulated that erythropoietin could modulate hepcidin synthesis.
Interventions
DRUGErythropoietin
Intravenous injection of 50 U/kg of erythropoietin
DRUGPlacebo
Intravenous injection of equivalent volume of saline serum
Sponsors
Rennes University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy volunteers * male aged 18 - 30 * normal routine laboratory values * normal ECG * normal iron status
Exclusion criteria
* C282Y mutation of the HFE gene * alcohol or tobacco consumption
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum hepcidin levels | over 24 hours |
Secondary
| Measure | Time frame |
|---|---|
| urinary hepcidin levels | over 24 hours |
| serum iron and ferritin levels | over 24 hours |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORFabrice LAINE, MD
Rennes University Hospital
STUDY_CHAIRBruno LAVIOLLE, MD
RennesUniversity Hospital
Outcome results
None listed