Peptic Ulcer Hemorrhage
Conditions
Keywords
Helicobacter pylori, Treatment, Upper gastrointestinal bleeding
Brief summary
The goal of the study is to compare the effectiveness of empirical Helicobacter pylori treatment compared with treatment depending on diagnostic tests for Helicobacter pylori in patients with Upper gastrointestinal bleeding due to peptic ulcer. Main hypothesis is that empirical treatment will reduce the number of patients lost to follow-up thus improving the cure rates of Hp infection.
Interventions
OTHEREmpirical Hp eradication
Empirical Helicobacter pylori treatment initiated immediately after oral intake is resumed
OTHEREradication treatment guided by a positive test
Eradication treatment given if there is at least one positive diagnostic test (URT, histological test, breath test or serology) for Helicobacter pylori.
Sponsors
Corporacion Parc Tauli
Consorcio Centro de Investigación Biomédica en Red (CIBER)
Hospital de Sabadell
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients older than 18. * Informed Consent signed. * Diagnosis of no variceal upper gastrointestinal bleeding secondary to a duodenal ulcer, erosive duodenitis or gastric ulcer. * Life expectancy longer than 6 months. * Able to attend further clinical controls. * Absence of the following
Exclusion criteria
.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Helicobacter pylori eradication rate | two years |
Secondary
| Measure | Time frame |
|---|---|
| Economical evaluation through cost-effectivity study of the empiric erradicator Helicobacter pylori treatment. | two years |
Countries
Spain
Contacts
Primary ContactPilar Garcia, Dra.
Backup ContactXavier Calvet, Dr.
Outcome results
None listed