Airway Hyperresponsiveness, Asthma
Conditions
Keywords
Asthma, Airway hyperresponsiveness, Swimmers, Airway inflammation, Airway remodelling
Brief summary
Swimmers show the highest prevalence of asthma among elite athletes, certainly due to chlorine exposure. The consequences of a chronic exposure to chlorine compounds by swimmers and the mechanisms of asthme in this population are still poorly documented. Specific diagnostic criteria have been proposed by the International Olympic Committee - Medical Council (IOC-MC) and World anti-doping agency (WADA) to determine the presence of asthma in athletes. Using the more specific bronchial provocation tests, our aims are 1. to compare the prevalence of asthma in swimmers and control subjects 2. to analyze the Influence of chlorine exposure on bronchial inflammatory processes in swimmers versus control subjects 3. to study the time-course of changes in airway symptoms, responsiveness, inflammation and remodeling after cessation of training
Interventions
None listed
Sponsors
Laval University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
14 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* 14 to 35 years old * To swim at least 10h per week * For control subjects, non-competitive healthy subjects
Exclusion criteria
* any disease that may interfere with the tests for the controls * Triathletes are excluded * Smokers * Obese or with a BMI more than 29 * Former athletes (control group)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Asthma and airway hyperreactivity prevalence in swimmers | 3 measurements in the year |
Secondary
| Measure | Time frame |
|---|---|
| Airway inflammation and remodeling in swimmers | 3 measurements in the year and a bronchial biopsy |
Countries
Canada
Contacts
Primary ContactValérie BOUGAULT, PhD
Backup ContactLouis-Philippe BOULET, MD
Outcome results
None listed