Two Strategies for Methicillin-resistant Staphylococcus Aureus (MRSA) Infection Prevention in Surgical Patients

An Interventional Study to Evaluate the Impact of Two Innovative Strategies in Preventing Nosocomial MRSA Infection in Surgical Patients

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00685867

Acronym

MOSAR-04

Enrollment

126750

Registered

2008-05-29

Start date

2008-05-31

Completion date

2010-12-31

Last updated

2012-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

MRSA Infection

Keywords

Staphylococcus aureus, Resistance, Prevention

Brief summary

The study is a two-arm controlled multi-centre trial of two strategies to reduce nosocomial MRSA transmission and infection among surgical patients. Enrolment and primary analyses will be performed at the hospital level. A total of ten adult surgical departments with at least 3 surgical subspecialties each will participate in the study. Sites of the study are located in 9 countries (UK, France, Spain, Germany, Switzerland, Italy, Serbia, Greece and Israel). The primary objective is to determine the effect of an early MRSA detection & decolonization & isolation strategy compared to an enhanced standard control strategy on healthcare-associated MRSA isolation rates among surgical patients at risk of MRSA carriage, who are hospitalized for at least 24 hours.

Interventions

OTHERRapid molecular MRSA test

PCR-based rapid screening for MRSA carriage

BEHAVIORALHand hygiene promotion

* Promotion and monitoring of hand hygiene, with special emphasis on alcohol-based hand rubs and feedback of hand hygiene compliance * Standard precautions (e.g. use of gloves for contacts with wounds and body fluids) * Isolation precautions according to the hospitals' capacity and strategy * Additional basic infection control interventions (if necessary)

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Surgical patients with LOS\>24h

Exclusion criteria

* Surgical patients with LOS\<24h

Design outcomes

Primary

Measure	Time frame
Nosocomial MRSA isolation rate (expressed as the monthly rate of MRSA in clinical isolates divided by the number of susceptible patients per hundred)	Monthly

Secondary

Measure	Time frame
Nosocomial MRSA infection rate (= number of nosocomial MRSA infections per 100 admissions)	Monthly

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 10, 2026