Chronic Renal Insufficiency
Conditions
Keywords
Redox state in the course of chronic renal insufficiency and hemodialysis.
Brief summary
The influence of hemodialysis on oxidative stress, endothelial activation, inflammation and on the redox state of lymphocytes should be clarified as well as the putative relationships between all these parameters.
Detailed description
Up to now, no anti-oxydative treatment has been able to reduce the mortality of the patients with Kidney Failure. Thus it is necessary to have a better knowledge of oxydative stress mechanisms in patients with KF in order to find more efficacious treatments. The influence of hemodialysis upon oxidative stress is not well known.
Interventions
OTHERSampling of blood
A sampling of blood will be made
Sponsors
Assistance Publique Hopitaux De Marseille
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* 18 and 80 years old man or woman dialysing at least 3 times a week for at least 6 months and having no residual renal function * Rate of haemoglobin \> 11 g / dl * Clinically stable patient that is having had no considerable event (cardiovascular problem, infection, surgical operation) with the exception of angioplasty of fistula or prosthesis vascular, in the previous 3 months the entrance to the study * Patient capable of understanding and of following the essay, in particular knowing how to read the note of information.
Exclusion criteria
* Pregnant woman * Treatment by corticoids or immunosuppresseurs * hemopathy sly * chronic cancer or infection in evolution * Cardiovascular event (infarct, unstable angor, coronary bypasses, confusions of the rhythm, AVC, amputation) or infectious (blood-poisoning, pneumopathie, meningitis) or surgical operation in the previous 3 months the inclusion in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| This study should allow to clarify the redox state some plasma by quantification of thiols membranous on the surface of lymphocytes at the hemodialysis and insufficient renal chronic not dialysed patients. | 48 months |
Secondary
| Measure | Time frame |
|---|---|
| This study should allow to estimate in a forward-looking longitudinal plan the possible involvement of the parameters of the redox state and the morbidity and the cardiovascular and global mortality in 2 years in 2 studied populations. | 48 months |
Countries
France
Outcome results
None listed