HPV Infections
Conditions
Brief summary
The aim of this study is to evaluate the significance of an elevated high-risk HPV (HR-HPV) viral load.
Detailed description
We will particularly evaluate if the HR-HPV viral load: * Is correlated to the transcription of the genes of the oncoproteins E6 and E7 * Is predictive of the integration of the virus in infected cells * Is predictive of the presence of HPV in patients' blood * Influences the local and systemic immunologic response
Interventions
OTHER2 cervical takings and 2 sampling of blood
* 2 cervical takings * 2 sampling of blood before and after the total hysterectomy
Sponsors
Assistance Publique Hopitaux De Marseille
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* The women consulting for the therapeutic care (by hysterectomy or conization) of a LIEHG or a cervical cancer (carcinoma epidermoid or adenocarcinoma) confirmed by the anatomopathologique analysis of a preoperative cervical biopsy. * The women having a normal cervix consulting for the surgical care by hysterectomy of a good-hearted pathology of the womb. The normality of the cervix will be confirmed by the anatomopathologique analysis of the detail of hysterectomy * The patients participating in this study will have to be of more than 18 years old. All the subjects will be profitable of a regime of Social Security.
Exclusion criteria
* The patients having a LIEBG * The patients incapable to receive the information enlightened on the progress and the objectives of the study * The patients not having signed enlightened assent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Estimate the meaning of a viral load raised in HPV oncogenic | 36 months |
Secondary
| Measure | Time frame |
|---|---|
| To estimate the correlation enters the vorale load of the HPV oncogenic and the severity of the cervical hurt | 36 months |
| Estimate the correlation between the viral load of the HPV oncogenic and the level of transcription of the genes coding for oncoproteines E6 and E7 | 36 months |
| Estimate the correlation between the viral load in HPV oncogenic and the integration of the viral genome in that of the infected cells | 36 months |
| Estimate the correlation between a viral load raised in HPV oncogenic and a presence of HPV in the circulating blood of the infected patients | 36 months |
Countries
France
Outcome results
None listed