Hemodynamic Measurements During Liver Transplantation

Comparing Different Methods For Measurement of Cardiac Output During Orthotopic Liver Transplantation

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00682110

Acronym

OLT

Enrollment

Registered

2008-05-22

Start date

2007-07-31

Completion date

2010-03-31

Last updated

2010-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Transplantation

Keywords

End-stage liver disease, Hemodynamic measurements, Hyperdynamic circulation, Pulmonary artery catheter, Cardiac output

Brief summary

The purpose of the study is to determine if the less invasive monitors are as reliable for measuring heart function in patients undergoing liver transplantation as the more invasive pulmonary artery.

Detailed description

Pulmonary artery catheter (PAC)is considered the gold standard in monitoring of heart function during orthotopic liver transplantation (OLT). Placement of PAC is very invasive (it passes thorough the heart chambers and into the pulmonary artery) and its benefits on the outcomes have not been proven. This study compares two newer FDA approved much less invasive devices to the PAC. The two new devices assess the heart function based either on the peripheral arterial waveform alone (Vigileo, Edwards Lifesciences)or the combination of peripheral arterial waveform and chemical indicator dilution (LiDCO, Cambridge, UK).

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients over 18 years of age * Scheduled for liver transplantation * Patient undergoing vascular surgery where invasive arterial pressure is indicated (control subjects)

Exclusion criteria

* We will exclude patients taking lithium based medication * Patients who weigh less than 40 kg; AND * Patients who are pregnant

Design outcomes

Primary

Measure	Time frame
Agreement between cardiac output measurements obtained with PAC, Vigileo and LiDCO	Specific phases of liver transplantation surgery

Countries

United States

Outcome results