Insulin Sensitivity and Substrate Metabolism in Patients With Cushing's Syndrome

Insulin Sensitivity and Substrate Metabolism in Patients With Cushing's Syndrome Before and After Surgical Treatment

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00682084

Enrollment

Registered

2008-05-22

Start date

2008-04-30

Completion date

2016-11-30

Last updated

2017-12-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cushing's Syndrome, Insulin Resistance

Keywords

Cushing's syndrome, Glucose tolerance, Insulin sensitivity, Substrate metabolism, Body composition

Brief summary

The purpose of this study is to investigate the effect og chronic elevated levels of cortisol on metabolism and insulin sensitivity.

Interventions

PROCEDURESurgery

Surgical removal of either a pituitary or ectopic ACTH producing tumor or an adrenal tumor

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Written consent * Age between 18 and 70 * Diagnosed with Cushing's syndrome

Exclusion criteria

* Suspected malignancy

Design outcomes

Primary

Measure	Time frame
Insulin sensitivity	Before and after treatment

Secondary

Measure	Time frame
Glucose tolerance, QoL, body composition, intrahepatic and intramyocellular fat, substrate metabolism.	Before and after treatment

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026