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Bilateral Training Versus Unilateral Training in Stroke

Bilateral Training for Upper Extremity Hemiparesis in Stroke

Status
Completed
Phases
Phase 2
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00681434
Enrollment
24
Registered
2008-05-21
Start date
2005-05-31
Completion date
Unknown
Last updated
2014-08-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemiparesis, Stroke

Keywords

stroke, upper extremity, hemiparesis

Brief summary

This randomized, single-blind study compares the effectiveness of bilateral training to unilateral training for individuals with moderate hemiparesis. We hypothesize that bilateral training will be superior to unilateral in the proximal extremity but not the distal one.

Detailed description

Upper extremity hemiparesis is the most common post-stroke disability. Longitudinal studies have indicated that 30 to 66 percent of stroke survivors do not have full arm function six months post-stroke. Bilateral arm training has been investigated as a potential rehabilitation intervention for individuals not eligible for constraint induced movement therapy. This training study included 24 hours of treatment over eight weeks. The protocol consisted of reaching activities with rhythmic auditory cueing emphasizing the proximal arm. Subjects assigned to the bilateral group performed bilateral symmetrical activities while subjects in the unilateral group performed the same activity with the affected arm only. The Motor Assessment Scale-Upper Limb Item and the Motor Status Scale are used as primary outcome measures. The Reaching Performance Scale and strength measures are secondary outcome measures. Assessments are administered pre-/ and post-training by a blind rater.

Interventions

BEHAVIORALbilateral upper extremity training

Bilateral symmetrical upper extremity training for proximal control for three hours per week for eight weeks.

BEHAVIORALUnilateral upper extremity training

Unilateral upper extremity training for proximal extremity for three hours a week for eight weeks.

Sponsors

Shirley Ryan AbilityLab
CollaboratorOTHER
University of Illinois at Chicago
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* cortical or subcortical stroke * chronic condition (at least six months prior) * ability to follow 2-step commands * ability to give consent

Exclusion criteria

* lesion in brain stem or cerebellum * visual field cut * neglect * uncontrolled hypertension * angina * COPD

Design outcomes

Primary

MeasureTime frame
Motor Assessment Scalepre and post (week one and week 8)
Motor Status Scalepre and post, Week 0 and Week eight

Secondary

MeasureTime frame
Reaching Performance Scalepre and post training (Week 0 and week 8)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026