COMT Gene Polymorphism
Conditions
Keywords
THC, COMT gene polymorphism, schizophrenia, cannabis use
Brief summary
This study attempts to examine genetic influences on the effects of tetrahydrocannabinol (Δ9-THC), the active ingredient of marijuana, cannabis, ganja, or pot.
Interventions
0.05 mg/kg of THC dissolved in ethanol intravenously over 20 minutes
Sponsors
National Institute on Drug Abuse (NIDA)
Yale University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* 18 and 55 years (extremes included) on the day of the first dosing.
Exclusion criteria
* Cannabis naïve individuals.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Behavioral Measures | Baseline, +15, +25, +60, +300 |
Countries
United States
Outcome results
None listed