Use of Functional Magnetic Resonance Imaging (fMRI) to Study Brain Activation in Children With Irritable Bowel Syndrome

Use of Functional Magnetic Resonance Imaging (fMRI) to Study Brain Activation Following Rectal Stimulation in Children With Irritable Bowel Syndrome

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00677976

Acronym

fMRI

Enrollment

Registered

2008-05-15

Start date

2007-06-30

Completion date

2013-06-30

Last updated

2020-04-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Irritable Bowel Syndrome

Keywords

fMRI, IBS, Brain Activation

Brief summary

The purpose of the study is to map regions of brain activation following rectal stimulation in children with irritable bowel syndrome (IBS) and healthy controls.

Detailed description

Our first aim is to compare the brain areas activated rectal stimulation in boys and girls with IBS and healthy children. Our second aim is to compare the anatomic regions of the brain activated during rectal stimulation in pre and post-pubertal male and female subjects between 10-18 yrs of age.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

10 Years to 18 Years

Healthy volunteers

Yes

Inclusion criteria

* Children aged 10 years to 18 years who provide written assent and whose parents provide written permission for participation * English-speaking * Subjects in the IBS group will meet Rome III criteria for IBS as determined by a pediatric gastroenterologist.

Exclusion criteria

* Other pain-related diseases, functional gastrointestinal disorders, or somatization disorder * Mental retardation or pervasive developmental disorder or epilepsy * Psychosis * Genetic or chromosomal disorders * Currently receiving psychoactive drug treatment * Patients with pacemakers, metal clips used in previous surgery or other device which are not compatible with MRI scanning * Inability to lie still in the scanner * Claustrophobia (Inability to lie still in the scanner) * Pregnancy * Subjects who admit to substance abuse during screening * Orthodontic braces

Design outcomes

Primary

Measure	Time frame
We intend to measure the degree of brain activation following rectal stimulation	4 years

Countries

United States

Outcome results