Sex Differences in Gene Expression in Human Adipose Tissue

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00677651

Enrollment

Registered

2008-05-14

Start date

2008-04-30

Completion date

2009-08-31

Last updated

2009-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy, Obesity

Keywords

adipose, lean, obese, overweight, healthy

Brief summary

This project was created to assess sex differences in adipose tissue gene expression in different locations in the body. The primary objectives are to understand: 1. The mechanisms of differential body fat distribution in men and women 2. How body fat distribution is affected by reproductive hormones 3. The mechanisms linking fat distribution to health risks such as diabetes

Interventions

PROCEDUREAdipose Biopsy

Adipose tissue will be sampled from the abdomen and buttock

PROCEDUREBlood sample

Blood will be sampled from an IV line

RADIATIONCT Scan

Single image at the level of the liver

RADIATIONDEXA

Whole body scan

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* Caucasian men and women 20-35 years of age * Lean (BMI less than 25) * Obese (BMI 30-35)

Exclusion criteria

* Hormonal birth control * Pregnancy * Smokers * History of diabetes, kidney, liver or thyroid disease * History of cancer

Design outcomes

Primary

Measure	Time frame
Adipose and blood sampling	1 year

Secondary

Measure	Time frame
CT scan and DEXA scan	1 year

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026