Allergens, House Dust Mites
Conditions
Keywords
house dust mite, asthma, autovaccine, allergy
Brief summary
House dust mite allergy is a common problem, resulting in asthma, chronic swelling of the eyes, and running nose. The investigators test a possibility to immunize subjects sensitized against house dust mite with extracts from their own gut bacteria auto-vaccination.
Detailed description
see above
Interventions
BIOLOGICALInjection of autovaccine (Autovaccine Symbiopharm)
increasing dosage schedule, six different concentrations, application over six weeks, 2 weeks break, another six weeks, 2 weeks break, than challenge with inhalative house dust mite extract
Sponsors
Johann Wolfgang Goethe University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* informed consent * age 18-35 years * known allergy on house-dust mite * GINA 0-1
Exclusion criteria
* anamnestic incompatibility to parts of autovaccine * asthma \> GINA I° * chronic disease conditions or infections * pregnancy * inhalative or systemic steroid use * any immunosuppressive therapy * intake of any other probiotic medication (e.g. E.coli nissle 1917) * participation in any other study at the same time * substance abuse * Incapability of understanding the study's purpose and performance * smoker
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patients' clinical parameters and behaviour, laboratory values | jul 2006 - august 2008 |
| laboratory testing reflecting function of bone marrow, liver, kidney | jul 2006- august 2008 |
Secondary
| Measure | Time frame |
|---|---|
| Lung function,exhalative NO | jul 2006 - oct 2007 |
Countries
Germany
Outcome results
None listed