Thrombectomy in Acute Myocardial Infarction

Aspiration Thrombectomy as an Adjunctive Therapy to Primary Angioplasty in Patients With ST Segment Elevation Myocardial Infarction

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00675480

Acronym

TAMI

Enrollment

140

Registered

2008-05-09

Start date

2004-11-30

Completion date

2008-09-30

Last updated

2009-01-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Myocardial Infarction

Keywords

myocardial infarction, thrombectomy, salvage index

Brief summary

The purpose of the study is to determine whether thrombus removal with aspiration thrombectomy for acute myocardial infarction reduces the infarct size.

Detailed description

Acute myocardial infarction is caused by an abrupt occlusion of coronary vessel or severe reduction of coronary flow. It has been shown that the reperfusion therapy significantly improves the clinical outcome. Currently the optimal strategy is the primary angioplasty with stent implantation. The treatment is recommended by AHA/ACC and ESC if can be performed within 90 minutes from the first medical contact. However there is still a certain percentage of procedure failure. To further improve the outcome new techniques and devices are tested . Aspiration thrombectomy may facilitate the reperfusion by reducing thrombus burden. The aim of the study is to assess if adjunctive thrombectomy may improve clinical outcome in patients with an acute ST segment elevation myocardial infarction.

Interventions

PROCEDUREThrombectomy

Aspiration Thrombectomy prior to stent implantation in patients with ST segment elevation myocardial infarction

PROCEDUREPrimary angioplasty

Standard primary angioplasty with stent implantation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

1. First acute myocardial infarction with ST segment elevation within 12 hours from pain onset 2. Culprit lesion in left anterior descending or right coronary artery. 3. Coronary flow assessed in TIMI scale ≤ 2 4. Presence of total coronary occlusion or angiographically visible thrombus in the culprit vessel 5. Patient signed informed consent

Exclusion criteria

1. Cardiogenic shock. 2. Culprit lesion in left circumflex coronary artery. 3. Status post coronary artery by-pass grafting 4. Previous myocardial infarction 5. Status post percutaneous coronary intervention.

Design outcomes

Primary

Measure	Time frame
Myocardial salvage index assessed with SPECT MIBI.	5-8 days

Secondary

Measure	Time frame
In hospital mortality	in hospital, before discharge
ST segment resolution after PCI;	90 minutes
CK-MB AUC	72 hours
Corrected TIMI frame count	immediately post PCI

Countries

Poland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026