PAOD (Peripheral Arterial Obstructive Disease)
Conditions
Brief summary
Given that previous studies demonstrated the feasibility of the required MRI techniques, we propose to study the macro- and microvascular adaptations in PAOD patients undergoing supervised exercise therapy. It is expected to provide valuable insights into the contribution of each vascular mechanism to the rehabilitation and to identify which vascular mechanism fails or is insufficient for a successful rehabilitation. Improvement of future treatment requires the identification of relevant adaptive mechanisms. With this we will provide early noninvasive MRI readout tools to diagnose and monitor the potential rehabilitation during any form of therapy for PAOD that affects the peripheral vasculature.
Interventions
OTHERsupervised treadmill exercise program
Supervised treadmill therapy consists of a walking exercise on a treadmill under supervision of a physiotherapist, 2-3 times a week. This program is combined with individual walking every other day and the total duration of the program is 6 months. Guided by the painfree walking distance, every month the angle and/or speed of the treadmill will increase. A standardized protocol for this type of therapy is already in use by many physiotherapists in Limburg (Willigendael, 2005).
Sponsors
Maastricht University Medical Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Intermittent claudication according to a positive Rose-Edingburgh questionnaire * Rest ankle-brachial pressure index (ABPI) \< 0,90 or 10% decline in ABPI after exercise * Arterial stenosis/occlusion of femoro-popliteal territory according to duplex/MRA measurements * Able to ondergo exercise therapy
Exclusion criteria
* Chronic or acute critical ischemia * Treated by or planned for vascular surgery or percutaneous transluminal angioplasty * Recent onset \<2 months * Unable to perform treadmill exercise * Diabetes mellitus * Contra-indications for (Gadolinium-enhanced) MRI or thigh cuff inflation
Countries
Netherlands
Contacts
Primary ContactBas Versluis
Outcome results
None listed