Linkage Analysis in Interstitial Cystitis

Genetic Studies of Urologic Chronic Pelvic Pain Syndrome

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00675298

Acronym

Enrollment

300

Registered

2008-05-09

Start date

2006-01-31

Completion date

2011-06-30

Last updated

2017-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Pelvic Pain Syndrome, Cystitis, Interstitial, Painful Bladder Syndrome, Prostatitis, Urinary Bladder, Overactive

Keywords

Prostatitis, Cystitis, Interstitial, Urinary Bladder, Overactive, Chronic pelvic pain syndrome, Painful bladder syndrome, Urgency, Frequency

Brief summary

Urologic pelvic pain syndrome (UCPPS), variably termed painful bladder syndrome/interstitial cystitis (PBS/IC) in females and chronic prostatitis/chronic pelvic pain syndrome in men (CP/CPPS), is a chronic, debilitating clinical syndrome presenting as severe pelvic pain with extreme urinary urgency and frequency in the absence of any known cause. The etiologic mechanisms underlying UCPPS are unknown, but recurrence, risks to siblings of affected individuals, concordance among monozygotic twins, and our own preliminary studies indicate a strong genetic contribution to the cause of UCPPS. The overall goal of this proposal is use novel approaches to understand the basis of UCPPS, to identify candidate genes containing mutations that result in UCPPS and determine how the different encoded proteins of these genes interact with one another in a common biological pathway. Ultimately, understanding how mutations in at least five different genes yield the symptoms of UCPPS should lead to improved diagnosis and possible therapies.

Interventions

None listed

Study design

Observational model

FAMILY_BASED

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

3 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* Have symptoms for at least 3 months within the preceding 6 months: * Pain in the pelvic area * Urinary frequency and/or * Urinary urgency and/or * Sexual dysfunction (erectile dysfunction) * Have CP/CPPS, IC, PBS, or BFS * Be willing to provide a saliva and urine sample * Agree to complete several brief questionnaires * Family of someone with CP/CPPS, PBS, IC or BFS * Live in the USA or Canada

Exclusion criteria

* Major structural/anatomical urinary tract abnormalities * Underlying inborn or congenital conditions

Countries

United States

Outcome results