Clonidine and Morphine in Caudal Anesthesia

Comparison of Clonidine and Morphine Plus Bupivacaine in Caudal Peridural Anesthesia for Postoperative Analgesia After Pediatric Urogenital Surgery

Status

Completed

Phases

Phase 1Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00672347

Enrollment

Registered

2008-05-06

Start date

2008-07-31

Completion date

2009-09-30

Last updated

2010-03-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Pain

Keywords

caudal anesthesia, clonidine, morphine, bupivacaine

Brief summary

Hypothesis: The combined use of Clonidine and Morphine in caudal anesthesia provides better postoperative analgesia than either drug alone after urogenital pediatric surgery.

Detailed description

It is a randomized, double blind study, involving 80 children with ages from 1 to 10 years old, submitted to urogenital surgery, under general anesthesia and caudal block. The patients will be divided into 4 groups: bupivacaine alone, bupivacaine plus clonidine, bupivacaine plus morphine, bupivacaine plus clonidine and morphine. The peroperative consumption of analgesics and inhaled gases, BIS, heart rate and arterial blood pressure will be recorded. Postoperative pain will be evaluated by using Wong-Baker faces scale and pain and discomfort score scale, as well as the consumption of analgesics.

Interventions

DRUGClonidine

1 mcg/kg

DRUGMorphine

20 mcg/kg

DRUGBupivacaine plus clonidine and morphine

bupivacaine 0,166% 1 ml/kg clonidine 1 mcg/kg morphine 20 mcg/kg

DRUGBupivacaine

Caudal anesthesia with bupivacaine 0,166% 1 ml/kg

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

1 Years to 10 Years

Healthy volunteers

Inclusion criteria

* Urogenital pediatric surgery * Status physical(ASA) 1 and 2

Exclusion criteria

* Cutaneous infection in puncture site

Design outcomes

Primary

Measure	Time frame
The overall postoperative consumption of analgesics.	24 hours

Secondary

Measure	Time frame
The peroperative consumption of volatile anesthetics.	3 hours
The peroperative Bispectral Index measure.	3 hours
Postoperative Wong-Baker faces scale	24 hours
Postoperative pain and discomfort score scale	24 hours

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026