Study Investigating MEN1 and SDHD in Familial Carcinoid Tumors

A Pilot Study to Investigate Germ-Line MEN1 and SDHD Gene Mutation in Familial Cases of Carcinoid Cancer

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00672269

Enrollment

Registered

2008-05-06

Start date

2008-04-30

Completion date

2010-06-30

Last updated

2009-02-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Carcinoid Neuroendocrine Cancer

Keywords

carcinoid, family members, familial, tumors, cancer

Brief summary

There is a high incidence among the first degree relatives of the carcinoid patients, indicating the involvement of genetic components in its initiation and pathogenesis.

Detailed description

This proposed pilot study will conduct detailed interviews into the medical, environmental, and family histories and to collect blood specimen to obtain DNA. The Blood specimen and DNA will be processed by the Rutgers University Cell and DNA Repository (RUCDR) to rule out Familial Multiple Endocrine Neoplasia (MEN 1), and succinate dehydrogenase complex, subunit D (SDHD), gene inactivation thought to be associated with different types of carcinoid cancer.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

12 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Over the age of 18 years 2. More than one ,member of a family with a history of biopsy confirmed carcinoid tumor 3. English speaking 4. Mentally and emotionally capable of answering questions 5. Willing and available for study participation 6. At least one other family member with carcinoid tumor

Exclusion criteria

1. If you are under the age of 18 years, 2. If you are unable to understand or unable to provide informed consent, 3. If you have a psychological condition (i.e. depression, anxiety disorder, substance abuse, etc.) which might cause you significant problems in dealing with test results.

Design outcomes

Primary

Measure	Time frame
Mutations in MEN1 and SDHD genes	1 year

Countries

United States

Contacts

Primary ContactNancy Gardner, PhD

gardnern@rutgers.edu813-731-0894

Backup ContactChangshun Shao, PhD

Shao@Biology.Rutgers.Edu

Outcome results