Obesity, Sleep Apnea, Obstructive
Conditions
Brief summary
Obstructive sleep apnea (OSA) is a syndrome characterized by repetitive episodes of airway obstruction during sleep, which result in low oxygen level in the blood and bad sleep quality. Both of these effects are implicated in medical, neurological and cognitive disorders in subjects with OSA. The purpose of this study is to examine how OSA affects medical and neurobehavioral outcomes after gastric bypass surgery for weight loss in morbidly obese patients.
Interventions
PROCEDURENeurocognitive Testing
Sponsors
Stanford University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
Scheduled for Laparoscopic roux-en-Y gastric bypass (RYGB) surgery Presence or absence of OSA confirmed by polysomnography Comprehension of spoken and written English
Exclusion criteria
Major psychiatric, neurological, or neuromuscular disorder History of untreated thyroid disease Known diabetes mellitus History of stroke with or without apparent neurological deficits Alcohol consumption which exceeds 2 drinks per day or drug abuse. Undergone a sleep study in the past
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The effect of preoperative OSA on the long term neurocognitive function after Roux-en-Y gastric bypass (RYGB) surgery for weight loss in morbidly obese patients | 1 year after surgery |
Secondary
| Measure | Time frame |
|---|---|
| The effect of preoperative neurocognitive impairment on the long term neurocognitive function after RYGB | 1 year after surgery |
| The effect of preoperative neurocognitive impairment on the weight loss function after RYGB and how this relates to the presence of OSA | 1 year after surgery |
Countries
United States
Outcome results
None listed