Cognitive Effects of Bariatric Surgery

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00671775

Enrollment

253

Registered

2008-05-05

Start date

2005-09-30

Completion date

2010-03-31

Last updated

2018-03-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bariatric Surgery Patients

Keywords

Bariatric Surgery, Obesity, Cognitive Function

Brief summary

There is growing evidence that obesity is associated with adverse neurocognitive outcome. Recent studies demonstrate that elevated body mass index (BMI) is an independent risk factor for Alzheimer's disease, structural brain abnormalities, and cognitive dysfunction in older adults. Preliminary work from our lab extends these findings and shows structural brain differences and cognitive dysfunction also exist in obese young and middle-aged adults. Bariatric surgery is increasingly viewed as an effective intervention for morbid obesity, though its effects on cognition are unknown. Post-operative nutritional deficiencies are common and can adversely impact cognitive performance. However, substantial weight loss resolves or improves many medical conditions with reversible cognitive effects, suggesting bariatric surgery may provide cognitive benefits. No study to date has examined the cognitive effects of bariatric surgery. To do so, the proposed study will prospectively assess cognitive performance in 125 bariatric surgery patients enrolled in the Longitudinal Assessment of Bariatric Surgery (LABS) project and 125 matched controls. Bariatric surgery patients will complete a computerized cognitive test battery at four time points: pre-operatively, 12 weeks post-operatively, 12 months post-operatively, and 24 months post-operatively. Matched control participants will complete the test battery at similar intervals. Demographic, medical, and psychosocial information will be collected to elucidate possible mechanisms of change. We hypothesize that the substantial weight loss following bariatric surgery will be associated with improved cognitive performance.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

25 Years to 70 Years

Healthy volunteers

Inclusion criteria

Specific criteria for bariatric surgery patients include: Inclusion Criteria * 25-65 years of age * Enrolled in LABS project * English-speaking

Exclusion criteria

* History of neurological disorder or injury (e.g. dementia, stroke, seizures) * Moderate or severe head injury (defined as \>10 minutes loss of consciousness; Alexander, 1995) * Past or current history of severe psychiatric illness (e.g. schizophrenia, bipolar disorder) * Past or current history of alcohol or drug abuse (defined by DSM-IV criteria) * History of learning disorder or developmental disability (defined by DSM-IV criteria) * Impaired sensory function Inclusion/

Countries

United States

Outcome results