Angiogenesis, Non-Small Cell Lung Cancer
Conditions
Keywords
Fluorine-18-α-methyltyrosine,, Positron emission tomography,, Fluorine-18-fluorodeoxyglucose,, Lung cancer,, Angiogenesis, The median VEGF rate was 45% (range, 10-78%)., High expression was seen in 30 patients (81%, 30/37)., VEGF expression was statistically associated with progressively growing microvessel count.
Brief summary
Purpose: L-\[3-18F\]-α-methyltyrosine (18F-FMT) is an amino-acid tracer for PET. We have conducted a clinicopathologic study to elucidate the correlation of angiogenesis with 18F-FMT and 18F-FDG uptake in the patients with non-small cell lung cancer (NSCLC). Method: Thirty-seven NSCLC patients were enrolled in this study, and a pair of PET study with 18F-FMT and 18F-FDG was performed. Uptake of PET tracers was evaluated with standardized uptake value. VEGF, CD31, CD34, LAT1 and Ki-67 labeling index of the resected tumors were analyzed by immunohistochemical staining, and correlated with the clinicopathologic variables and the uptake of PET tracers.
Interventions
None listed
Sponsors
J~pharma
Gunma University
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients who underwent a thoracotomy within 4 weeks after 18F-FMT PET and 18F-FDG PET study * Histology is non-small cell lung cancer
Exclusion criteria
* Patient who received neoadjuvant chemotherapy or radiotherapy before surgery * Patients who have insulin-dependent diabetes
Countries
Japan
Outcome results
None listed