Candidemia, Invasive Candidiasis
Conditions
Keywords
candidemia, invasive candidiasis, Ambisome, liposomal amphotericin B
Brief summary
Patients will receive 2mg/kg/day IV daily administration of AmBisome® over 30-60 minutes as a reaction to signs/symptoms and positive Candida culture
Detailed description
Subjects will be enrolled to receive intravenously AmBisome® at 2 mg/kg/day for a maximum of 4 weeks. Treatment will be discontinued in case of failure, adverse events precluding treatment or success. In case of success AmBisome® at 2 mg/kg/day should be administered for at least 5 days after the complete resolution of all clinical findings of an active infection or for at least 8 days after the last positive blood culture or culture from a normally sterile site. It is not recommended to declare failure (and therefore change treatment) before giving at least 5 days of antifungal therapy. Failures in patients given less than 5 days of treatment should be well documented (e.g. persistent positive cultures despite catheter removal, clinical deterioration in absence of any explanation other than the fungal infection). Follow-up evaluations will be conducted at 2 and 4 weeks after the end of AmBisome® therapy. At end of treatment (time point for success or failure) patients may be shifted to oral (not intravenous) antifungals at the discretion of the local investigator, once a complete response has been achieved, if secondary prophylaxis is deemed necessary.
Interventions
DRUGAmBisome
Patients will receive 2mg/kg/day IV daily administration of AmBisome® over 30-60 minutes as a reaction to signs/symptoms and positive Candida culture
Sponsors
Gilead Sciences
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
14 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients admitted to ICU for all medical reasons that meet the inclusion criteria * Males or non pregnant females (women of child-bearing potential must have a negative serum or urine pregnancy test at baseline). * Subjects who are 14 years old or older. * Subjects with at least one positive blood culture isolation of a Candida spp. from a specimen or from a normally sterile site (including abdominal catheters), drawn within 96 hours prior to study entry. * Subjects who have clinical evidence of infection AT SOME TIME WITHIN 48 HOURS PRIOR TO ENROLLMENT, including AT LEAST ONE of the following: 1. temperature\> 38°C on 2 occasions at least 4 hours apart or one determination greater than 38.5°C (internal, at oesophagus, tympani or bladder levels). 2. systolic blood pressure \< 90, or a \>30 mm Hg decrease in systolic BP from the subject's normal baseline. 3. Signs of inflammation (swelling, heat, erythema, purulent drainage) from a site infected with Candida * Subjects or their legal representative (but the subject should sign it in any case when able to) must sign a written informed consent form. Written informed consent must be obtained before any study-related procedure is carried out.
Exclusion criteria
* Subjects with a history of allergy or intolerance to AmBisome® * Subjects who have received systemic antifungal therapy within 15 days prior to inclusion in the study * Any severe cardiovascular disease (such as arrhythmias, in particular) which may constitute a contra-indication to AmBisome® administration * Subjects with an absolute neutrophil count of less than 500/mm3 in the 48 hours before enrolment in the study * Subjects with a diagnosis of AIDS (positive HIV serology in association with either CD4 cell counts \< 200 cells/mm3or history of an opportunistic infection /neoplasm), aplastic anemia, or Chronic Granulomatous Disease. * Subjects with moderate or severe liver disease defined as any one or more of the following: \* Alkaline phosphatase, ALT, AST, or total bilirubin greater than 5 times the ULN (upper limit of normal) * Subjects with a severe renal impairment defined by a serum creatinine of more than 2.5 mg/dL. * Women who are pregnant or breastfeeding. * Subjects who are unlikely to survive more than 24 hours. * Subjects who previously participated in this study. * Subjects who have received within the two weeks before study entry, are receiving or likely to receive any investigational drug (unlicensed new chemical entity).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Success at End of Trial (EOT) - Success is defined as: The definition of success is (criteria a, b, c and d must be satisfied): a. i) Absence of all clinical signs and symptoms present at baseline and absence of any new signs and symptoms that may be | Through 4 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Efficacy at the 2nd and 4th week after the end of therapy | Through 4th week |
| Safety of the 2 mg/kg/day regimen | Through 4 weeks |
Countries
Italy
Outcome results
None listed