Wrist Cartilage - High Resolution in Vivo MR T2 Mapping- a Feasibility Study

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00669201

Enrollment

Registered

2008-04-30

Start date

2007-12-31

Completion date

Unknown

Last updated

2008-04-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis

Keywords

cartilage, osteoarthritis, T2 mapping, MRI, Wrist

Brief summary

Purpose:Evaluate the feasibility of T2 cartilage mapping on MRI of the wrist and correlate with T2 mapping of knee cartilage. Study protocol: Phase 1. 10 healthy volunteers, Phase 2. 10 volunteers with osteoarthritis of the wrist, Phase 3. 50 patients for studies for routine MR of the wrist. MRI protocol: 3 T unit((Signa EXITE HDx),T1, T2 and T2 mapping sequences on axial and coronal orientation.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* Phase 1. Age:18-40 * Phase 2: No age limit, known OA on pre-existing X-rays * Phase 3: No age limit, routine MRI of the wrist

Exclusion criteria

* Phase 1, 2: wrist trauma/surgery * All phases: any contraindication for MR: eg metals, claustrophobia, etc.

Design outcomes

Primary

Measure	Time frame
wrist bone cartilage thickness can be measured and stratification can be observed on T2 mapping with correlation to T2 mapping of the knee cartilage	Within MRI completion (20 minutes)

Countries

Israel

Outcome results