Periodontitis
Conditions
Keywords
chronic periodontitis, antibiotic resistance
Brief summary
This study will look at the safety of using the study medicine for a long time. It will see if the germs get used to the medicine, making it not work as well, if it's used by people with gum disease for a long time.
Detailed description
The objective of this study is to evaluate the changes in populations of minocycline-resistant bacteria after long-term use of minocycline HCl microspheres, 1 mg in subjects with moderate-to-severe chronic periodontitis. This will be assessed through monitoring the total number and proportion of minocycline-resistant bacteria and the identity of minocycline-resistant species within a panel of 40 representative periodontal species in saliva and subgingival plaque.
Interventions
At Baseline and all interim visits, a single unit dose of 1mg minocycline HCl (with approximately 3mg PGLA) will be professionally administered subgingivally into periodontal pockets at each site exhibiting a PD ≥ 5mm.
Sponsors
OraPharma
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
25 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* generally healthy * over 25 years of age * moderate-to-severe chronic periodontitis * documented informed consent * willing to comply with contraceptive requirements * free from any significant oral soft tissue pathology
Exclusion criteria
* willing to adhere to prohibitions and restrictions of the study * oral health inappropriate for study inclusion * females self-reporting pregnancy or lactation, or having a positive urine pregnancy result * reporting any of the following conditions: * allergy to a tetracycline-class drug * systemic medical conditions requiring antibiotic prophylaxis prior to invasive dental procedures * active systemic infectious disease such as hepatitis, human immunodeficiency virus (HIV) or tuberculosis * diagnosed with clinically significant or unstable organic disease, or compromised healing potential, heart murmurs, histories of rheumatic fever, valvular disease or prosthetic joint replacement * participation in a dental clinical trial or use of an investigational drug within 30 days of enrollment * employees of the Investigator or study center, with direct involvement in the proposed study or other studies, as well as family members of the employees or the Investigator * anyone who the investigator determines should not be included in the study for any reason that could compromise safety or the analysis of study results
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Percent of Minocycline-Resistant Bacteria Using Bacterial Culture | from Baseline to Day 30 and Day 180 | Percentage Change from Baseline is calculated as post-baseline percent minus baseline percent. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Micocycline-Resistance From Plaque Samples | Baseline, Day 30 and Day 180 | Percentage of Subjects showing Micocycline-Resistance for each Species from Plaque Samples DNA Method: Plaque Sample Intent-to-Treat Subjects - we report average of percentage for 4 plaque samples |
| Micocycline-Resistance From Saliva Sample | Baseline, Day 30 and Day 180 | Percentage of Subjects Showing Micocycline-Resistance for each Species from Saliva Sample DNA Method: Saliva Sample Intent-to-treat Subjects |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Minocycline HCl Microspheres A single unit dose of 1mg minocycline HCl (with approximately 3mg PGLA) professionally administered subgingivally into periodontal pockets at each site exhibiting a PD ≥ 5mm | 23 |
| No Drug Intervention A control consisting of no drug intervention | 12 |
| Total | 35 |
Withdrawals & dropouts
| Period | Reason | FG000 | FG001 |
|---|---|---|---|
| Overall Study | Lost to Follow-up | 2 | 1 |
Baseline characteristics
| Characteristic | Minocycline HCl Microspheres | No Drug Intervention | Total |
|---|---|---|---|
| Age Continuous | 57.65 years STANDARD_DEVIATION 10.71 | 52.83 years STANDARD_DEVIATION 9.9 | 56.00 years STANDARD_DEVIATION 10.55 |
| Region of Enrollment United States | 23 participants | 12 participants | 35 participants |
| Sex: Female, Male Female | 9 Participants | 2 Participants | 11 Participants |
| Sex: Female, Male Male | 14 Participants | 10 Participants | 24 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk |
|---|---|---|
| deaths Total, all-cause mortality | — / — | — / — |
| other Total, other adverse events | 8 / 23 | 7 / 12 |
| serious Total, serious adverse events | 1 / 23 | 1 / 12 |
Outcome results
Primary
Change in Percent of Minocycline-Resistant Bacteria Using Bacterial Culture
Percentage Change from Baseline is calculated as post-baseline percent minus baseline percent.
Time frame: from Baseline to Day 30 and Day 180
Population: intention to treat (ITT)
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Minocycline HCl Microspheres | Change in Percent of Minocycline-Resistant Bacteria Using Bacterial Culture | Plaque Sample at Day 30 | 13.15 Percentage Change | Standard Deviation 19.77 |
| Minocycline HCl Microspheres | Change in Percent of Minocycline-Resistant Bacteria Using Bacterial Culture | Saliva Sample at Day 30 | 37.65 Percentage Change | Standard Deviation 113.9 |
| Minocycline HCl Microspheres | Change in Percent of Minocycline-Resistant Bacteria Using Bacterial Culture | Plaque Sample at Day 180 | 8.09 Percentage Change | Standard Deviation 19.77 |
| Minocycline HCl Microspheres | Change in Percent of Minocycline-Resistant Bacteria Using Bacterial Culture | Saliva Sample at Day 180 | 12.06 Percentage Change | Standard Deviation 18.35 |
| No Drug Intervention | Change in Percent of Minocycline-Resistant Bacteria Using Bacterial Culture | Saliva Sample at Day 180 | -0.51 Percentage Change | Standard Deviation 10.7 |
| No Drug Intervention | Change in Percent of Minocycline-Resistant Bacteria Using Bacterial Culture | Plaque Sample at Day 30 | 0.81 Percentage Change | Standard Deviation 3.33 |
| No Drug Intervention | Change in Percent of Minocycline-Resistant Bacteria Using Bacterial Culture | Plaque Sample at Day 180 | 1.58 Percentage Change | Standard Deviation 2.49 |
| No Drug Intervention | Change in Percent of Minocycline-Resistant Bacteria Using Bacterial Culture | Saliva Sample at Day 30 | -2.25 Percentage Change | Standard Deviation 6.18 |
Secondary
Micocycline-Resistance From Plaque Samples
Percentage of Subjects showing Micocycline-Resistance for each Species from Plaque Samples DNA Method: Plaque Sample Intent-to-Treat Subjects - we report average of percentage for 4 plaque samples
Time frame: Baseline, Day 30 and Day 180
Population: ITT
| Arm | Measure | Group | Value (NUMBER) |
|---|---|---|---|
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | V.parvula | 41.67 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | A.naeslundii | 7.14 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | S.constellatus | 65.48 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | E.nodatum | 3.57 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | P.gingivalis | 29.76 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | A.actinomucetemcomitans | 7.14 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | F.nucleatum vincentii | 7.14 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | C.rectus | 9.52 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | R.dentocariosa | 0.00 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | E.saburreum | 16.67 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | P.micra | 8.33 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | A.oris | 19.05 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | S.anginosus | 30.95 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | S.anguinis | 76.19 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | A.gerencseriae | 3.57 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | S.oralis | 70.24 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | C.ochraccea | 1.19 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | A.israelli | 0.00 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | S.intermedius | 48.81 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | C.matruchotti | 2.38 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | P.nigrescens | 5.95 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | A.odontolyticus | 4.76 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | F.nucleatum polymorphum | 11.90 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | C.showae | 4.76 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | F.periodonticum | 1.19 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | N.mucosa | 35.71 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | F.nucleatum | 1.19 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | C.ginigivaluis | 15.48 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | S.gordonii | 72.62 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | T.forsythia | 1.19 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | S.noxia | 51.19 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | P.acnes | 1.19 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | P.melaninogenica | 7.14 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | S.mitis | 75.00 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | E.corrodens | 53.57 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | G.morbillorum | 22.62 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | C.sputigena | 1.19 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | L.bucallis | 34.52 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | C.gracilis | 7.14 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Plaque Samples | P.intermedia | 29.76 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | V.parvula | 71.43 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | E.saburreum | 16.67 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | A.naeslundii | 1.19 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | F.nucleatum | 3.57 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | S.mitis | 79.76 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | A.gerencseriae | 10.71 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | R.dentocariosa | 2.38 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | P.gingivalis | 21.43 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | F.nucleatum polymorphum | 25.00 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | P.melaninogenica | 3.57 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | G.morbillorum | 22.62 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | S.oralis | 78.57 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | A.oris | 13.10 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | C.rectus | 13.10 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | P.acnes | 8.33 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | A.odontolyticus | 19.05 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | P.nigrescens | 8.33 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | C.ochraccea | 0.00 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | E.nodatum | 3.57 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | F.periodonticum | 9.52 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | S.noxia | 65.48 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | E.corrodens | 57.14 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | C.sputigena | 0.00 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | A.israelli | 2.38 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | S.anginosus | 30.95 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | A.actinomucetemcomitans | 16.67 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | L.bucallis | 21.43 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | T.forsythia | 2.38 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | F.nucleatum vincentii | 11.90 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | S.intermedius | 65.48 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | S.constellatus | 67.86 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | P.intermedia | 19.05 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | C.gracilis | 4.76 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | C.showae | 10.71 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | P.micra | 15.48 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | C.matruchotti | 3.57 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | N.mucosa | 27.38 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | S.anguinis | 85.71 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | S.gordonii | 91.67 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Plaque Samples | C.ginigivaluis | 17.86 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | C.ginigivaluis | 7.14 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | P.nigrescens | 3.57 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | F.nucleatum | 0.00 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | N.mucosa | 58.33 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | A.odontolyticus | 21.43 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | F.periodonticum | 2.38 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | P.gingivalis | 7.14 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | F.nucleatum polymorphum | 16.67 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | R.dentocariosa | 5.95 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | L.bucallis | 28.57 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | C.showae | 7.14 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | V.parvula | 53.57 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | C.rectus | 11.90 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | E.nodatum | 13.10 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | A.oris | 7.14 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | F.nucleatum vincentii | 9.52 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | S.constellatus | 73.81 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | G.morbillorum | 78.57 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | S.anginosus | 34.52 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | A.naeslundii | 17.86 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | E.corrodens | 42.86 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | S.anguinis | 88.10 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | S.mitis | 75.00 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | A.gerencseriae | 2.38 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | E.saburreum | 65.48 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | P.melaninogenica | 2.38 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | P.acnes | 10.71 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | S.oralis | 82.14 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | S.noxia | 55.95 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | P.intermedia | 36.90 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | C.ochraccea | 1.19 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | A.actinomucetemcomitans | 19.05 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | C.gracilis | 4.76 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | A.israelli | 2.38 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | T.forsythia | 0.00 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | C.sputigena | 3.57 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | S.intermedius | 76.19 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | S.gordonii | 69.05 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | C.matruchotti | 8.33 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Plaque Samples | P.micra | 23.81 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | C.rectus | 22.73 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | R.dentocariosa | 9.09 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | E.saburreum | 25.00 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | P.micra | 29.55 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | E.nodatum | 11.36 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | V.parvula | 47.73 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | A.oris | 25.00 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | S.anginosus | 50.00 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | G.morbillorum | 36.36 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | S.anguinis | 75.00 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | A.gerencseriae | 6.82 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | S.oralis | 77.27 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | C.ochraccea | 2.27 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | A.israelli | 2.27 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | S.intermedius | 63.64 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | C.sputigena | 4.55 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | C.matruchotti | 4.55 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | P.nigrescens | 11.36 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | A.odontolyticus | 25.00 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | P.intermedia | 27.27 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | F.nucleatum polymorphum | 13.64 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | C.showae | 34.09 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | F.periodonticum | 2.27 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | L.bucallis | 29.55 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | N.mucosa | 36.36 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | F.nucleatum | 0.00 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | C.ginigivaluis | 20.45 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | S.gordonii | 81.82 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | T.forsythia | 0.00 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | S.noxia | 65.91 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | C.gracilis | 4.55 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | P.acnes | 9.09 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | P.melaninogenica | 2.27 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | S.mitis | 81.82 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | A.naeslundii | 6.82 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | S.constellatus | 79.55 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | P.gingivalis | 29.55 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | A.actinomucetemcomitans | 22.73 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | F.nucleatum vincentii | 9.09 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Plaque Samples | E.corrodens | 65.91 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | C.matruchotti | 6.82 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | C.ochraccea | 0.00 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | S.anguinis | 77.27 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | E.saburreum | 18.18 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | F.nucleatum vincentii | 9.09 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | A.naeslundii | 6.82 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | E.corrodens | 52.27 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | S.mitis | 77.27 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | S.anginosus | 59.09 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | S.noxia | 54.55 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | S.gordonii | 75.00 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | S.constellatus | 70.45 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | C.ginigivaluis | 15.91 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | S.oralis | 79.55 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | A.oris | 20.45 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | S.intermedius | 63.64 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | E.nodatum | 6.82 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | C.sputigena | 0.00 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | P.acnes | 11.36 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | V.parvula | 54.55 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | A.israelli | 0.00 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | C.rectus | 13.64 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | C.showae | 15.91 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | C.gracilis | 0.00 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | A.actinomucetemcomitans | 25.00 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | F.nucleatum polymorphum | 15.91 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | A.gerencseriae | 6.82 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | P.gingivalis | 15.91 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | F.periodonticum | 0.00 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | R.dentocariosa | 9.09 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | P.melaninogenica | 2.27 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | A.odontolyticus | 20.45 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | T.forsythia | 0.00 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | P.micra | 22.73 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | N.mucosa | 36.36 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | P.intermedia | 18.18 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | L.bucallis | 20.45 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | G.morbillorum | 22.73 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | P.nigrescens | 2.27 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Plaque Samples | F.nucleatum | 0.00 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | E.saburreum | 65.91 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | F.nucleatum | 0.00 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | L.bucallis | 15.91 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | C.matruchotti | 0.00 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | C.ginigivaluis | 2.27 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | S.intermedius | 81.82 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | S.gordonii | 77.27 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | A.israelli | 0.00 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | T.forsythia | 2.27 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | C.ochraccea | 0.00 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | S.oralis | 88.64 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | A.actinomucetemcomitans | 11.36 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | S.noxia | 50.00 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | E.corrodens | 25.00 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | G.morbillorum | 88.64 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | R.dentocariosa | 2.27 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | P.acnes | 11.36 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | A.gerencseriae | 0.00 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | P.melaninogenica | 13.64 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | C.gracilis | 0.00 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | S.anguinis | 90.91 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | C.rectus | 11.36 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | S.anginosus | 50.00 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | A.naeslundii | 13.64 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | A.oris | 2.27 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | F.nucleatum vincentii | 9.09 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | S.constellatus | 81.82 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | S.mitis | 90.91 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | V.parvula | 31.82 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | E.nodatum | 13.64 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | P.intermedia | 31.82 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | P.micra | 9.09 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | C.showae | 15.91 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | F.nucleatum polymorphum | 13.64 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | A.odontolyticus | 9.09 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | F.periodonticum | 0.00 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | P.gingivalis | 2.27 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | C.sputigena | 4.55 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | N.mucosa | 61.36 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Plaque Samples | P.nigrescens | 9.09 Percentage of Subjects |
Secondary
Micocycline-Resistance From Saliva Sample
Percentage of Subjects Showing Micocycline-Resistance for each Species from Saliva Sample DNA Method: Saliva Sample Intent-to-treat Subjects
Time frame: Baseline, Day 30 and Day 180
Population: ITT
| Arm | Measure | Group | Value (NUMBER) |
|---|---|---|---|
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | V.parvula | 61.90 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | S.constellatus | 47.62 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | E.nodatum | 4.76 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | P.gingivalis | 23.81 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | A.actinomucetemcomitans | 19.05 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | F.nucleatum vincentii | 9.52 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | C.rectus | 9.52 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | R.dentocariosa | 4.76 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | E.saburreum | 19.05 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | P.micra | 14.29 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | A.naeslundii | 4.76 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | A.oris | 14.29 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | S.anginosus | 14.29 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | S.anguinis | 61.90 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | A.gerencseriae | 4.76 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | S.oralis | 66.67 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | C.ochraccea | 0.00 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | A.israelli | 0.00 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | S.intermedius | 42.86 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | C.matruchotti | 9.52 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | P.nigrescens | 9.52 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | A.odontolyticus | 23.81 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | F.nucleatum polymorphum | 19.05 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | C.showae | 19.05 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | F.periodonticum | 4.76 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | N.mucosa | 47.62 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | F.nucleatum | 0.00 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | C.ginigivaluis | 23.81 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | S.gordonii | 71.43 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | T.forsythia | 0.00 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | S.noxia | 52.38 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | P.acnes | 9.52 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | P.melaninogenica | 0.00 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | S.mitis | 61.90 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | E.corrodens | 57.14 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | G.morbillorum | 38.10 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | C.sputigena | 9.52 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | L.bucallis | 33.33 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | C.gracilis | 0.00 Percentage of Subjects |
| Minocycline HCl Microspheres | Micocycline-Resistance From Saliva Sample | P.intermedia | 23.81 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | C.ginigivaluis | 9.52 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | P.nigrescens | 4.76 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | F.nucleatum | 0.00 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | A.odontolyticus | 19.05 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | A.actinomucetemcomitans | 9.52 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | N.mucosa | 28.57 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | F.nucleatum polymorphum | 19.05 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | P.intermedia | 19.05 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | F.periodonticum | 4.76 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | L.bucallis | 23.81 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | C.showae | 9.52 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | V.parvula | 90.48 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | P.gingivalis | 19.05 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | G.morbillorum | 14.29 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | A.oris | 14.29 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | C.rectus | 9.52 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | E.nodatum | 0.00 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | S.anginosus | 14.29 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | S.constellatus | 42.86 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | S.anguinis | 85.71 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | E.saburreum | 14.29 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | A.naeslundii | 0.00 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | S.mitis | 71.43 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | A.gerencseriae | 14.29 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | P.melaninogenica | 0.00 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | S.oralis | 71.43 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | R.dentocariosa | 0.00 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | P.acnes | 9.52 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | C.ochraccea | 0.00 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | F.nucleatum vincentii | 0.00 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | S.noxia | 52.38 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | C.sputigena | 4.76 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | A.israelli | 0.00 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | E.corrodens | 47.62 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | T.forsythia | 0.00 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | S.intermedius | 38.10 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | C.gracilis | 0.00 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | P.micra | 9.52 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | C.matruchotti | 9.52 Percentage of Subjects |
| No Drug Intervention | Micocycline-Resistance From Saliva Sample | S.gordonii | 85.71 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | S.anguinis | 100.00 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | S.intermedius | 80.95 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | P.nigrescens | 0.00 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | R.dentocariosa | 14.29 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | F.nucleatum | 9.52 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | C.gracilis | 4.76 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | N.mucosa | 76.19 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | S.mitis | 90.48 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | A.odontolyticus | 28.57 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | A.actinomucetemcomitans | 14.29 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | C.matruchotti | 23.81 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | F.periodonticum | 4.76 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | P.gingivalis | 9.52 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | A.gerencseriae | 9.52 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | F.nucleatum polymorphum | 14.29 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | E.saburreum | 61.90 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | P.melaninogenica | 19.05 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | L.bucallis | 38.10 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | A.israelli | 0.00 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | P.acnes | 19.05 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | C.showae | 4.76 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | S.gordonii | 66.67 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | V.parvula | 80.95 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | C.rectus | 14.29 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | S.oralis | 100.00 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | E.nodatum | 14.29 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | T.forsythia | 0.00 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | P.micra | 23.81 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | A.oris | 14.29 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | S.noxia | 57.14 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | P.intermedia | 33.33 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | S.constellatus | 80.95 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | G.morbillorum | 76.19 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | C.sputigena | 0.00 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | S.anginosus | 42.86 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | E.corrodens | 57.14 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | C.ochraccea | 4.76 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | A.naeslundii | 19.05 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | F.nucleatum vincentii | 19.05 Percentage of Subjects |
| Micocycline Group at 180 Days | Micocycline-Resistance From Saliva Sample | C.ginigivaluis | 19.05 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | C.rectus | 18.18 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | E.corrodens | 72.73 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | R.dentocariosa | 9.09 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | E.saburreum | 27.27 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | P.micra | 18.18 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | V.parvula | 81.82 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | A.oris | 27.27 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | S.anginosus | 27.27 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | G.morbillorum | 27.27 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | S.anguinis | 72.73 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | A.gerencseriae | 9.09 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | S.oralis | 63.64 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | C.ochraccea | 9.09 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | A.israelli | 9.09 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | S.intermedius | 63.64 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | C.sputigena | 9.09 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | C.matruchotti | 9.09 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | P.nigrescens | 0.00 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | A.odontolyticus | 45.45 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | P.intermedia | 18.18 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | F.nucleatum polymorphum | 9.09 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | C.showae | 36.36 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | F.periodonticum | 9.09 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | L.bucallis | 18.18 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | N.mucosa | 36.36 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | F.nucleatum | 0.00 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | C.ginigivaluis | 18.18 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | S.gordonii | 72.73 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | T.forsythia | 0.00 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | S.noxia | 54.55 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | C.gracilis | 0.00 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | P.acnes | 9.09 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | P.melaninogenica | 18.18 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | A.naeslundii | 9.09 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | S.mitis | 81.82 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | S.constellatus | 72.73 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | E.nodatum | 9.09 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | P.gingivalis | 27.27 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | A.actinomucetemcomitans | 27.27 Percentage of Subjects |
| Control Group at Baseline | Micocycline-Resistance From Saliva Sample | F.nucleatum vincentii | 9.09 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | V.parvula | 81.82 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | C.sputigena | 0.00 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | C.ginigivaluis | 0.00 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | P.intermedia | 27.27 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | C.matruchotti | 9.09 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | S.gordonii | 45.45 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | S.intermedius | 45.45 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | A.israelli | 0.00 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | A.actinomucetemcomitans | 0.00 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | T.forsythia | 0.00 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | C.ochraccea | 0.00 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | S.noxia | 54.55 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | S.oralis | 90.91 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | E.saburreum | 0.00 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | P.acnes | 0.00 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | C.gracilis | 0.00 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | A.gerencseriae | 0.00 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | E.corrodens | 81.82 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | P.melaninogenica | 18.18 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | G.morbillorum | 0.00 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | S.anguinis | 72.73 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | C.rectus | 0.00 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | A.naeslundii | 9.09 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | F.nucleatum vincentii | 0.00 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | S.anginosus | 9.09 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | S.constellatus | 63.64 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | S.mitis | 90.91 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | A.oris | 18.18 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | E.nodatum | 0.00 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | F.nucleatum | 0.00 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | R.dentocariosa | 0.00 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | C.showae | 0.00 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | F.nucleatum polymorphum | 9.09 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | P.gingivalis | 18.18 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | F.periodonticum | 0.00 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | A.odontolyticus | 0.00 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | N.mucosa | 27.27 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | L.bucallis | 9.09 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | P.nigrescens | 0.00 Percentage of Subjects |
| Control Group at 30 Days | Micocycline-Resistance From Saliva Sample | P.micra | 0.00 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | S.anguinis | 100.00 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | F.nucleatum | 9.09 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | L.bucallis | 27.27 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | P.micra | 18.18 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | C.matruchotti | 36.36 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | E.corrodens | 45.45 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | S.anginosus | 45.45 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | C.ginigivaluis | 9.09 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | P.gingivalis | 18.18 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | N.mucosa | 72.73 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | S.intermedius | 90.91 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | C.rectus | 0.00 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | A.naeslundii | 0.00 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | S.gordonii | 72.73 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | C.showae | 9.09 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | A.israelli | 0.00 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | F.nucleatum polymorphum | 27.27 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | A.oris | 9.09 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | F.nucleatum vincentii | 18.18 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | T.forsythia | 0.00 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | C.ochraccea | 0.00 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | C.sputigena | 0.00 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | S.oralis | 90.91 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | A.actinomucetemcomitans | 27.27 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | S.constellatus | 63.64 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | S.noxia | 72.73 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | E.saburreum | 72.73 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | A.odontolyticus | 36.36 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | G.morbillorum | 100.00 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | P.intermedia | 54.55 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | V.parvula | 90.91 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | P.acnes | 27.27 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | R.dentocariosa | 9.09 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | A.gerencseriae | 9.09 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | P.nigrescens | 0.00 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | E.nodatum | 9.09 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | S.mitis | 100.00 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | P.melaninogenica | 0.00 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | C.gracilis | 0.00 Percentage of Subjects |
| Control Group at 180 Days | Micocycline-Resistance From Saliva Sample | F.periodonticum | 0.00 Percentage of Subjects |