Type 2 Diabetes
Conditions
Brief summary
A randomised, cross-over trial targeting a small sample of older (age 45-65 years) overweight adults with type 2 diabetes the aims of this pilot study are to: 1. Determine the feasibility of investigating the acute effects of prolonged sedentary behaviour (sitting) in this target group. 2. Compare the acute effects of a single prolonged (8 hour) bout of sedentary behaviour (sitting) on glucose and triglyceride concentrations and key muscle and adipose regulatory enzymes to a similar bout of sedentary behaviour combined with intermittent bouts of light-intensity activity.
Detailed description
The proposed study will involve a randomised cross-over experimental trial conducted in the laboratory setting in older overweight adults with type 2 diabetes. Participants will receive both of the acute testing conditions in a randomised manner. Study design: Randomised cross-over pilot trial of 20 overweight/obese older adults with diet-controlled type 2 diabetes involving 2 acute treatment conditions, with a one-week wash-out period between testing conditions (Figure 1 a). Setting: Acute, supervised laboratory setting within the Alfred and Baker Heart Institute Medical Unit. Outcomes: We will measure acute responses in laboratory-measured plasma glucose & triglyceride levels (every 60 mins) and glucose concentrations determined from continuous glucose monitoring (CGMS).
Interventions
None listed
Sponsors
International Diabetes Institute, Australia
Baker Heart Research Institute
Bayside Health
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
45 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
1. Diet controlled Diabetes 2. Overweight (BMI \> 27 kg/m2 but \<50 kg/m2)
Exclusion criteria
1. Hypoglycaemic Agents 2. Lipid Lowering Agents
Countries
Australia
Outcome results
None listed