Airway Hyperresponsiveness, Asthma
Conditions
Keywords
nitric oxide, bronchospasm, anesthesia, induced sputum, asthma
Brief summary
Intraoperative bronchospasm challenges anesthesia's safety. This study aims to investigate high concentration of exhaled nitric oxide as a marker of intraoperative bronchospasm.
Detailed description
Previous studies in asthmatic patients suggested that exhaled nitric oxide may represent a noninvasive measure for airway inflammation. Anesthesia information forms from 1999 throughout 2004 were revised (n=146.358). Bronchospasm occurrence appeared registered on 863 forms. From those, nine were identified as non-asthmatics patients (Bronchospasm group). Also, 12 asthmatics constituted one additional group (Asthma group) and 10 subjects with no previous airway disease or symptoms (Control group). All subjects were submitted to Exhaled nitric oxide measurements (parts/billion), spirometry and induced sputum.
Interventions
None listed
Sponsors
University of Sao Paulo
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
16 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* patients with no systemic disease and registered bronchospasm during anesthesia induction
Exclusion criteria
* hypertension, COPD, diabetes, pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Exhaled nitric oxide in parts per billion | one to six months after surgery |
Secondary
| Measure | Time frame |
|---|---|
| Eosinophils concentration within sputum sample, pulmonary function tests | one to six months after surgery |
Countries
Brazil
Outcome results
None listed