Hypopituitarism
Conditions
Keywords
Patients with hypopituitarism
Brief summary
In contrast to healthy subjects, patients with hypopituitarism do not exhibit endocrine responses when hormones are injected. This is at least true for those with a complete insufficiency of the anterior pituitary. For example, administration of corticotropin releasing hormone (CRH) is not followed by an increase of ACTH and cortisol. Therefore, pure hormone effects can be investigated. It is well established that hormones of the hypothalamic-pituitary-adrenal axis are involved in sleep regulation. In rodents, CRH decreased slow wave sleep (SWS). In humans, CRH was reported to increase wakefulness and to decrease SWS and REM sleep. Primary objective was therefore to study the effect of CRH on patients with hypopituitarism. To date, there is no information on sleep of patients with hypopituitarism. Secondary objective is therefore to compare sleep of patients with hypopituitarism with sleep of age-matched healthy controls.
Interventions
OTHERcorticotropin releasing hormone (CRH)
50 µg injected at 2200, 2300, 0000, and 0100
OTHERPlacebo
injected at 2200, 2300, 0000, and 0100
Sponsors
Max-Planck-Institute of Psychiatry
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
Patients with hypopituitarism Inclusion Criteria: * Age 18-75 years * Complete insufficiency of the anterior pituitary * Stable hormone substitution for at least 3 months
Exclusion criteria
* Hormone excess in the past * Sleep disorder, e.g. sleep apnea syndrome Healthy controls Inclusion Criteria: * Age 18-75 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sleep-EEG variables, conventionally and quantitatively analyzed | within the first month |
Countries
Germany
Outcome results
None listed