Pain
Conditions
Keywords
shoulder surgery, analgesia
Brief summary
Sixty adults having shoulder and forearm surgery will receive either placebo or celebrex started preoperatively and continued for 3 days. Rescue medications required as well as pain scores will be assessed using a patient diary to evaluate the effect of celebrex in controlling transitional pain
Interventions
DRUGcelebrex
400 mg celebrex given 1 hour preop and celebrex 200 mg BID postop
DRUGplacebo
placebo given preop and BID postop
Sponsors
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Patients scheduled for elective ambulatory surgery of the shoulder * ASA I - III * Able to read English * Male or female
Exclusion criteria
* Allergy to local anesthetic, Cox2, sulpha drug, acetaminophen or oxycodone * Women who are pregnant or lactating and women of childbearing age and not following acceptable contraceptive precautions * Any major medical or psychiatric problem * Those with a known history of narcotic dependence, abuse or chronic narcotic intake * Patients with known history of peptic ulcer or GI bleeding in the past, ulcers, congestive heart failure, angina or previous heart attack, coagulation problems, venous thrombosis, kidney or liver disease or strokes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| visual analogue score for pain | post-op period |
Secondary
| Measure | Time frame |
|---|---|
| severity of nausea | post-op period |
Countries
Canada
Outcome results
None listed