Joint Stiffness Following Knee Replacement Surgery

Capsular Changes in Joint Contractures Post-Knee Arthroplasty:A Case-Control Study

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00664651

Enrollment

Registered

2008-04-23

Start date

2006-12-31

Completion date

2015-04-30

Last updated

2015-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Joint Contracture

Keywords

joint contracture, total knee arthroplasty

Brief summary

Our primary research question is to find out whether there is a genetic component to the development of joint contractures following knee surgery, through the application of lab techniques.

Detailed description

After total knee replacement surgery, some people develop joint stiffness, which is also called a joint contracture. Contractures cause the envelope of the knee (called the capsule) to stiffen and become rigid so the patient can no longer move their knee the way they used to. After stretching and other exercises, only a surgery can try and divide or remove the contracture. The main purpose of this research is to study the cause of the contracture and specifically if certain people are predisposed to contractures.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

-knee contractures post arthroplasty scheduled for arthrotomy with debridement of capsular tissue Controls will be patients scheduled for arthrotomy with debridement of capsular tissue for the other reasons(primary knee arthroplasty, ORIF of the knee secondary to trauma, ACL repair, amputation, elective joint arthroplasty with capsuloplasty etc.) Exclusion: * transmissible disease (HIV, Hep B,C) * confirmed or suspected neoplasia * suspected infection

Design outcomes

Primary

Measure	Time frame
Gene expression	Dec 2015

Countries

Canada

Outcome results