Matrix Metalloproteinase (MMP) in Heart Failure

MMP is Produced in Failing Hearts

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00663494

Enrollment

Registered

2008-04-22

Start date

2003-02-28

Completion date

2006-07-31

Last updated

2011-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Stable Heart Failure

Keywords

heart failure, MMP, coronary sinus

Brief summary

The purpose of this study is to evaluate the production of MMP in failing hearts.

Detailed description

Myocardial fibrosis is observed in failing hearts and parallel to the progression of chronic heart failure (CHF) and myocardial remodeling. Matrix metalloproteinases (MMPs) are considered markers of fibrosis. Recently, circulating MMPs can be measured and are elevated in patients with CHF. However, MMPs it is still unclear whether MMPs are produced in failing hearts. Thus, the purpose of this study is to evaluate the production of MMP in failing hearts.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Inclusion criteria

* chronic stable heart failure

Design outcomes

Primary

Measure	Time frame
MMPs level of coronary sinus	—

Outcome results