Critical Illness
Conditions
Keywords
critical illness, hypoglycemia, neurocognitive dysfunction, intensive insulin therapy
Brief summary
Hypoglycemia occurs frequently during intensive blood glucose control in critically ill patients. The incidence of hypoglycaemia is associated with impaired outcome. However, it is hitherto unknown if hypoglycaemia itself predisposes patients to neurological impairment, e.g. cognitive dysfunction, or if it is the underlying medical condition that makes the patient prone to a high risk of hypoglycaemia and, concomitantly, neurocognitive impairment. Therefore we investigate neurocognitive function in patients who had hypoglycemias during their intensive care stay and compare the results to patients without hypoglycaemia whose medical conditions are matched to the hypoglycaemia patients.
Interventions
None listed
Sponsors
University Hospital Muenster
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* all patients
Exclusion criteria
* clinical diagnosis of diabetes mellitus * brain injury of any kind prior to or upon ICU-admission * pre-existing mental or psychiatric disorder * terminal kidney or liver failure prior admission * drug abuse, * CPR \> 5 min * HIV * Lues
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| neurocognitive function | 1 year after ICU discharge |
Secondary
| Measure | Time frame |
|---|---|
| neurocognitive function | 2,3, and 4 years after ICU discharge |
Countries
Germany
Outcome results
None listed