Pharmacology and Physiology of the Lower Urinary Tract

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00662064

Enrollment

200

Registered

2008-04-21

Start date

2002-02-28

Completion date

2008-12-31

Last updated

2008-06-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Urologic Diseases

Keywords

Lower urinary tract, Physiology, Pathology, Immunohistochemistry, Urinary bladder

Brief summary

The function of the lower urinary tract is simple - urine storage and voiding. However, despite this simplicity of function, the control of the lower urinary tract is a rather complex, multilevel process (urothelium, detrusor, peripheral nerves, spinal cord and higher cerebral centres) and the mechanisms involved remain poorly elucidated. This study is designed to gain a more in depth understanding of the lower urinary tract function. Using bladder biopsies, tissue staining for characteristic markers present on nerves and other cells will be performed. We hypothesize that certain markers are altered in disease and turn back towards the control level of healthy people or patients with successful medical treatment.

Interventions

None listed

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Patients with lower urinary tract dysfunction * Controls with normal lower urinary tract function

Exclusion criteria

* Age \< 18 years old * Pregnancy

Design outcomes

Primary

Measure	Time frame
Immunohistochemistry + PCR of bladder tissue	not specified (storage of biopsies)

Countries

United Kingdom

Contacts

Primary ContactThomas M Kessler, MD

tkessler@gmx.ch44-207-829-8713

Backup ContactShahid Khan, MD

drshahidkhan@gmail.com44-207-829-8713

Outcome results