Olfaction Disorders
Conditions
Keywords
smell, olfaction, olfactory sensitivity, smell loss, chemoreception
Brief summary
Signal processing in the olfactory neuron could be influenced by inhibition of enzymes like phosphodiesterase. Pentoxifylline is a unspecific phosphodiesterase inhibitor. The hypothesis is that pentoxifylline could lead to increased sensitivity to odors.
Detailed description
Olfactory signal processing is conducted by a G-protein linked increase of intracellular concentration of adenosine 3´,5´-cyclic monophosphate (cAMP). In the cilia of olfactory sensory neurons (OSN) cAMP is degraded by phosphodiesterase 1C2 (PDE1C2). Inhibition of PDE1C2 could result in an increased response of OSN to chemical stimuli. Aim of the present prospective post-marketing surveillance study was to investigate the impact of pentoxifylline, an unspecific phosphodieasterase inhibitor, on olfactory function.
Interventions
DRUGPentoxifylline retard 400mg
Agapurin retard 400mg 3/day per os for 3 weeks
Sponsors
Technische Universität Dresden
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* hyposmic or functionally anosmic patients TDI-score \<31 * age: 18-50 years * odor threshold: better than 1 * cause of smell loss: post traumatic, postinflammatory, idiopathic
Exclusion criteria
* normosmic patients, * patients with contraindications for application of pentoxifylline * patients that cannot give written agreement to the study * patients under 18 years and over 50 years of age
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TDI-score | at day 0 and follow up after 3 weeks |
Secondary
| Measure | Time frame |
|---|---|
| odor threshold odor discrimination odor identification | at day 0 and at follow up after 3 weeks |
Countries
Germany
Outcome results
None listed