The Role of Central Serotonergic and Adrenergic Systems in the Effectiveness of DNIC (Diffuse Noxious Inhibitory Control

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00660751

Enrollment

Registered

2008-04-17

Start date

2007-08-31

Completion date

2012-04-30

Last updated

2017-10-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

Physiology of Serotonergic and Adrenergic systems

Brief summary

The role of central serotonergic and adrenergic systems in the effectiveness of DNIC (Diffuse Noxious Inhibitory Control) will be tested before and after taking Duloxetine and Placebo in a double blind study.

Interventions

DRUGDuloxetine

SNRIs

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy volunteers * age 18-80 * no chronic disease

Exclusion criteria

* Subjects who suffer from chronic pain / pain syndrome * use of anti-depressant or anti-psychotic drugs * food/ drugs sensitivity * breast feeding

Design outcomes

Primary

Measure	Time frame
level of DNIC	1 week

Countries

Israel

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026