Endothelial Dysfunction Induced by Postprandial Lipemia

Endothelial Dysfunction Induced by Postprandial Lipemia: Complete Protection Afforded by High Intensity Aerobic Interval Exercise

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00660491

Enrollment

Registered

2008-04-17

Start date

2008-01-31

Completion date

2008-10-31

Last updated

2012-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Subjects

Keywords

flow mediated dilatation, maximal oxygen uptake, blood lipid

Brief summary

Postprandial lipemia and exercise oppose each other in terms of cardiovascular risk, however the mechanism of their interaction is not well understood. Therefore we want to study vascular function, as assessed by brachial artery (BA) flow mediated dilation (FMD), in healthy men before and after a high fat meal (HFM) preceded (16-18 hrs) by rest, a single bout of continuous moderate intensity exercise (CME), and high intensity interval exercise (HIIE).

Interventions

OTHERexercise training

moderate intensity exercise group, and high intensity exercise group

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender

MALE

Age

20 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* male, 20-40years, BMI between 25 and 30, resident in Trondheim.

Exclusion criteria

* unstable angina, CHD, heart failure,

Design outcomes

Primary

Measure	Time frame
Flow mediated dilatation	baseline, post exercise, 30min, 2hour, 4hour post exercise

Secondary

Measure	Time frame
blood lipid profile	same as flow mediated dilatation

Countries

Norway

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 4, 2026