Exploring the Relationship Between Varying CO2 Levels and the Regional BOLD Signal, by Using Breathing Exercises

Exploring the Relationship Between Varying CO2 Levels and the Regional BOLD Signal, by Using Breathing Exercises .

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00660465

Enrollment

Registered

2008-04-17

Start date

2008-05-31

Completion date

Unknown

Last updated

2014-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

Regional BOLD signal dependency on arterial PaCO2., Effect of breathing exercises on brain regional O2 level., Healthy subjects

Brief summary

The purpose of this study is to explore how arterial PaCO2 effect regional Blood Oxygen Level Dependent (BOLD) signal, and indirectly the brain regional O2 level .

Detailed description

Among many parameters effecting cerebral blood flow(CBF), partial pressure of CO2 (PaCO2) in arterial blood has a significant effect. A small increase in arterial PaCO2 level will cause a significant increase of CBF , followed by increase of O2 level . The main objective is to explore the effect of arterial PaCO2 level on regional CBF and brain O2 level, by using breathing exercises to modulate arterial PaCO2. The regional Blood Oxygen Level Dependent (BOLD) signal produced by MRI , will indicate the regional O2 level.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

* adults over 18 years old .

Exclusion criteria

* under 18 years old. * Artificial pacemaker * implantable cardioverter-defibrillator (ICD) * Hearing aid, implantable or portable. * artificial heart valve * Surgical clips * Metal fragments in eyes * Electronic stimulators * Implanted pumps * Implantable Neurostimulation Device * metal fragments of any sort * Permanent makeup or tattoo * transfusion pump * pregnant or breast feeding women * False teeth , retainer or dental crown

Countries

Israel

Contacts

Primary ContactAlexander Gersten, Ph.D

alex.gersten@gmail.com+972-52-3906012

Outcome results