Prostate Cancer
Conditions
Keywords
Exercise, Prostatic, Neoplasm, Androgen, Deprivation
Brief summary
The purpose of this study is to determine the effectiveness of a four months strength training program on physical and psychological health in patients with prostate cancer during androgen deprivation therapy. It is hypothesized a beneficial effect of the intervention on physical and psychological health in patients with prostate cancer treated with androgen deprivation.
Interventions
BEHAVIORALStrength training group
After 5-10 months on androgen deprivation therapy the patients in the intervention group go through a four months strength training intervention. The patients will perform three strength-training sessions per week, two under supervision of a sport instructor. Each session will consists of one-three sets of nine strength-training exercises, performed at an intensity of 6 or 10 repetitions of maximum (6-10 RM).
Sponsors
Ullevaal University Hospital
Norwegian School of Sport Sciences
University of Alberta
University of Oslo
Norwegian Foundation for Health and Rehabilitation
The Royal Norwegian Ministry of Health
Oslo University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
No minimum to 75 Years
Healthy volunteers
No
Inclusion criteria
* Newly diagnosed locally advanced prostate cancer (clinical stage T2 and T3) * Referred to RH and UUS for radiotherapy * \< 75 years * Capable of reading and writing Norwegian * Treating oncologist must approve of the subjects' participation * Living within approximately 1 hour from Oslo by car or public transportation
Exclusion criteria
* Routinely resistance training with manuals * Medication for osteoporosis (i.e. bisphosphonates) * Conditions of a severity that contraindicate exercise without adjusted actions * Mentally incompetent conditions * Conditions of a severity that complicates the ability to participate in a supervised training program
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| lean body mass | before ADT, before and after the intervention |
Secondary
| Measure | Time frame |
|---|---|
| bone mineral density, fat mass, body mass index, serological outcomes (including lipids, hormones and CRP), physical functioning, psycho-social functioning and muscle cellular outcomes (including muscle fiber size and function) | before ADT, before and after the intervention |
Countries
Norway
Outcome results
None listed