Cirrhosis With Ascites
Conditions
Keywords
Cirrhosis, Ascites, Adrenal insufficiency, Hepatorenal syndrome, Portal hypertension
Brief summary
Relative adrenal insufficiency (RAI) is an well known condition in patients with septic shock. Liver failure (including chronic liver failure)and sepsis are both characterized by hyperdynamic circulatory failure (with low arterial pressure) and high levels of pro-inflammatory cytokines. Hydrocortisone has been shown to have a beneficial effect on clinical outcome. The aim of this study is to evaluate the incidence of RAI in the different settings of ascites in cirrhosis and the usefulness of hydrocortisone in this context.
Interventions
DRUGhydrocortisone
50 mg/6 h per day
DRUGdextrose solution 5%
dextrose solution 5% 100 ml/6 h per day
Sponsors
University of Turin, Italy
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Cirrhosis with ascites, with or without hepatorenal syndrome
Exclusion criteria
* Age \< 18 and \> 75 years * Shock or bacterial infection present at the inclusion or during the previous week * Bleeding present at the inclusion or during the previous week * Multifocal HCC * Organic renal failure * Hearth or pulmonary failure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| renal function | 10 days |
Countries
Italy
Contacts
Primary ContactCarlo Alessandria, MD
Backup ContactMonica Carello, MD
Outcome results
None listed