Chronic Pain
Conditions
Keywords
Pain
Brief summary
The MGH Center for Translational Pain Research is seeking patients with chronic pain for a research study. The study is looking at the effect of opioid (narcotic) pain medicines on pain sensation, threshold and tolerance.
Detailed description
The study consists of one visit, in which an interview, physical exam, lab work (urine test) and sensory testing will be done. The testing (Quantitative Sensory Testing) is noninvasive (no needles) and involves heat and cold stimulation. Compensation and some parking reimbursement provided.
Interventions
QST consists of a series of heat and cold stimulation tests.
Sponsors
Massachusetts General Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
a. Inclusion/
Exclusion criteria
Inclusion Criteria for the group with chronic pain on chronic treatment with opioids: 1. Subject has chronic pain and is on stable chronic opioid treatment (morphine, fentanyl, oxycodone, methadone, hydromorphone, hydrocodone) for chronic pain for at least one month. We consider stable treatment if no change in the type and amount of daily opioid treatment for one month. Only patients with minimal daily opioid dose of at least 30 mg morphine equianalgesic dose will be included. 2. Subject is age 18 to 65 years. Inclusion Criteria for the group with chronic pain on chronic treatment with non-opioids (currently not recruiting): 1. Subject has pain and is on stable chronic non-opioid treatment for chronic pain for at least one month. 2. Subject is age 18 to 65 years. Inclusion Criteria for the group of opioid-naive healthy volunteers without chronic pain (currently not recruiting): 1. Subject is opioid naive meaning he/she did not receive chronic opioid treatment in the past or present, and did not receive acute treatment with opioids in the last 1 month 2. Subject does not have pain 3. Subject is age 18 to 65 years.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Response to warm/cold temperature | 2 hours | Responses to warm/cold temperatures will be recorded by the Quantitative Sensory Testing device (QST). |
Countries
United States
Outcome results
None listed