Preemptive Analgesia for Postlaminectomy

Intraoperative Perineural Injection of Lidocaine for Postlaminectomy Pain

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00656526

Enrollment

Registered

2008-04-11

Start date

2007-09-30

Completion date

2007-12-31

Last updated

2008-04-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Laminectomy

Keywords

analgesia, postlaminectomy , lidocaine, dorsal root

Brief summary

To relieve post laminectomy pain, we have tried intraoperative perineural injection of lidocaine right after the exposure in expecting that this would be preemptive analgesia by blocking the nerve transmission so that postoperative pain starts later and lighter.

Detailed description

A randomized double-blind 40 patients aged 18-50 of ASA I and II undergoing laminectomy were included in the study. All the patients were followed for their heart rate, arterial pressure , respiratory rate, oxygen saturation, end tidal CO2 and postoperative VAS scores. All the patients were premedicated with midazolam 0.1 mg/kg intramuscularly 40 minutes prior to surgery. The induction was made 2 mg/kg propofol, 1 ug/kg remifentanyl, 0.5mg/kg rocuronium. After the orotracheal intubation anesthesia was maintained with isoflurane (%0.5-2.0) and 0.1 mg/kg rocuronium.Just before the exposure of dorsal root, 0.5 cc %2 lidocaine was injected on the dorsal root.The patients postoperative analgesic period, VAS scores and additional analgesic need was recorded. For the postoperative analgesia tramadol 1 mg/kg tramadol was used.

Interventions

DRUGLidocaine, perineural injection, intraoperatively

0.5 cc lidocaine, one single injection over the dorsal root.

DRUGLidocaine

0.5 cc %2 lidocaine,single injection

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Inclusion criteria

* laminectomy * 18-50 age * ASA 1-2 * both sex

Exclusion criteria

* under 18 or older than 50 * any disease other than back pain\\ * ASA 3-4

Design outcomes

Primary

Measure	Time frame
In the laminectomy operation, right after the exposure of the dorsal root , an injection of lidocaine attenuates postoperative pain.	postoperative 24 hours

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026