Examining the Long-Term Risks of Oophorectomy

Ovarian Conservation: Long-Term Health Outcomes From the Nurse's Health Study.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00655447

Enrollment

32175

Registered

2008-04-09

Start date

1980-01-31

Completion date

2004-06-30

Last updated

2008-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast Cancer, Cancer, Coronary Heart Disease, Death, Hip Fracture, Ovarian Cancer, Stroke

Keywords

oophorectomy, ovarian conservation, stroke, breast cancer, ovarian cancer, other cancer, hip fracture

Brief summary

At the time of hysterectomy for benign disease, the overall health benefits of preserving ovarian function in a large population of women have not been established.

Detailed description

We are conducting a prospective, observational study of 32,175 women participants of the Nurse's Health Study who had a hysterectomy with or without removal of both ovaries. We are evaluating mortality and morbidity due to the following conditions: coronary heart disease, stroke, breast cancer, ovarian cancer, other cancer, hip fracture and death from all causes.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

30 Years to 55 Years

Healthy volunteers

Yes

Inclusion criteria

* Women who had hysterectomies were classified into simple hysterectomy or hysterectomy with both ovaries removed.

Exclusion criteria

* Evidence of cancer, coronary heart disease (MI or Angina Pectoris), stroke, or hip fracture before entering the study were excluded. Cancer as an indication for hysterectomy also excluded. * Women reporting unilateral oophorectomy, unknown oophorectomy status, unknown age of hysterectomy, or those who had oophorectomy before hysterectomy were excluded.

Design outcomes

Primary

Measure	Time frame
mortality and morbidity due to the following conditions: coronary heart disease, stroke, breast cancer, ovarian cancer, other cancer, hip fracture and death from all causes.	28 years

Secondary

Measure	Time frame
The effect of postmenopausal hormone use on mortality and morbidity due to the following conditions: coronary heart disease, stroke, breast cancer, ovarian cancer, other cancer, hip fracture and death from all causes.	28 years

Countries

United States

Outcome results