Conjunctivitis, Allergic
Conditions
Keywords
Allergic conjunctivitis, Allergic rhinoconjunctivitis
Brief summary
To compare the clinical efficacy of olopatadine and fluticasone in a 3-week single center, double-masked, randomized, placebo controlled parallel treatment conjunctival allergen challenge (CAC) study in patients with allergic conjunctivitis
Detailed description
Study will evaluate the efficacy of nasal anti-allergic therapy compared to ocular anti-allergic therapy in the prevention of ocular allergic symptoms.
Interventions
DRUGOlopatadine
Ophthalmic solution
DRUGFluticasone
Nasal spray
DRUGSaline
Nasal spray
DRUGArtificial tears
Ophthalmic Solution
Sponsors
Greiner, Jack V., OD DO PhD
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* At least 18 years of age & either sex, any race * Willing and able to follow all instructions and attend all study visits * Positive history of ocular allergies * Reproducible positive ocular allergic reaction induced by conjunctival allergen challenge
Exclusion criteria
* Have planned surgery during trial period * Female currently pregnant, planning a pregnancy, or lactating * Use of disallowed medications
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ocular itching | Minutes following CAC |
Secondary
| Measure | Time frame |
|---|---|
| Ocular redness | Minutes following CAC |
Countries
United States
Outcome results
None listed