Hypercholesterolemia
Conditions
Keywords
Cholesterol, hypercholesterolemia, low density lipoproteins
Brief summary
To compare the efficacy of various doses of rosuvastatin with atorvastatin, pravastatin & simvastatin in reducing levels of low density lipoprotein cholesterol in subjects with hypercholesterolaemia.
Interventions
DRUGRosuvastatin
DRUGAtorvastatin
DRUGPravastatin
DRUGSimvastatin
Sponsors
AstraZeneca
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Discontinuation of all previous lipid lowering therapy. * Fasting LDL-c levels of between 160mg/dl - 250 mg/dl at Visits 2 & 3 for subjects not on lipid lowering therapy at Visit 1. * Other lipid parameters as specified in the protocol.
Exclusion criteria
* The use of lipid lowering drugs or dietary supplements after Visit 1. * Active arterial disease eg Unstable angina, or recent arterial surgery * Abnormal laboratory parameters as defined in the protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage change in low density lipoprotein cholesterol. | 4 & 6 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Percentage change in other lipid parameters as defined by the protocol | 6 weeks |
| Safety evaluation | 6 weeks |
Outcome results
None listed