Effect of Prophylaxy of Amiodarone and Propranolol and Amiodarone With Propranolol in Prevention of Atrial Fibrillation Post Coronary Artery Bypass Graft

Effect of Prophylaxy of Amiodarone and Propranolol and Amiodarone With Propranolol in Prevention of Atrial Fibrillation Post Coronary Artery Bypass Graft, A Prospective Double-Blind Randomized Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00654290

Enrollment

240

Registered

2008-04-07

Start date

2007-03-31

Completion date

2008-02-29

Last updated

2008-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial Fibrillation

Keywords

Atrial fibrillation, coronary bypass, Amiodarone, Propranolol, Coronary Artery Bypass Graft (CABG)

Brief summary

Atrial fibrillation is the most common arrhythmia post coronary bypass surgery, currently B-blockers are the class I indication to prevent AF post CABG. We decide to evaluate use of propranolol and amiodarone separately and together to find a better prophylaxis for AF peri-CABG

Detailed description

In this double blind randomized study 240 consecutive patients underwent elective coronary artery bypass grafting, being randomized prospectively into three groups, propranolol (p) (n=80), amiodarone (A) (n=80) and amiodarone with propranolol (AP) (n=80). All groups received their medications from 7 days preoperatively and continued their medications for 5 days post CABG.

Interventions

DRUGAmiodarone + Propranolol

Amiodarone and Propranolol 7 days pre-operation to 5 days post CABG

DRUGAmiodarone

Amiodarone treated 7 days pre-operation to 5 days post CABG

DRUGPropranolol

Propranolol from 7 days pre-operation to 5 days post CABG

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

45 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Patient who are going to have elective CABG * Signing informed consent

Exclusion criteria

* EF\<35% * Bradycardia\<60 per min * Hypotension\< 100 mmhg

Design outcomes

Primary

Measure	Time frame
incidence of atrial fibrillation post CABG	7 days post CABG

Secondary

Measure	Time frame
bradycardia, mortality, hypotension, morbidity	7 days post CABG

Countries

Iran

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 3, 2026