Right Sided Cardiac Failure
Conditions
Brief summary
This is an unblinded pilot study comparing (against a randomized control day without water immersion) the diuretic and natriuretic effects of water immersion in patients with right heart failure.
Detailed description
Patients will be immersed in a tub for 3 hours (on one day) and neurohormones will be obtained before and after immersion. Urine will be collected for quantification and evaluation of sodium concentration.
Interventions
PROCEDUREWater immersion
Subjects will sit in tub for four hours.
Sponsors
University of Maryland, Baltimore
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients must have right sided failure secondary to right ventricular dysfunction, pulmonary hypertension, or tricuspid regurgitation * Age greater than 18 years of age * Right heart catheterization within the last year to rule out left-sided failure. * Evidence of fluid overload as indicated by 2 or more of the following: 1.) 2+ or more pitting edema of the lower extremities, 2.) scrotal or penile edema, 3.) JVP greater than or equal to 10 cm, 4.) abdominal ascites
Exclusion criteria
* Pulmonary capillary wedge pressure above 16 mmHg or history of elevated left ventricular filling pressures. * Serum creatinine \> 2.0 * Current use of an angiotensin I converting enzyme inhibitor or angiotensin receptor blocker will preclude participation in the RAS neurohormone portion of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diuresis | 4 hours |
Secondary
| Measure | Time frame |
|---|---|
| Neurohormonal activation | 4 hours |
| Natriuresis | 4 hours |
Countries
United States
Outcome results
None listed