Racial Differences: Nitric Oxide(NO) and Endothelin-1(ET-1) in Preeclampsia (PreE)

Elucidating the Role of Nitric Oxide and Endothelin-1 Activation in Endothelial Cells Co-cultured With Placental Explants From African-american and Caucasian High Risk Pregnancies

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00653809

Enrollment

Registered

2008-04-07

Start date

2007-06-30

Completion date

2009-09-30

Last updated

2012-04-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preeclampsia

Brief summary

The goal of this study is to examine the activation of markers of endothelial and cardiovascular dysfunctions, from women with high-risk pregnancies. Information from this study will hopefully provide enough information to determine a link between race, the advent of high risk pregnancies and cardiovascular markers. With this information it might be possible to intervene with approved pharmacological treatments.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 40 Years

Healthy volunteers

Inclusion criteria

* African-american or Caucasian * Pregnant * Between ages of 18 - 40 years of age

Exclusion criteria

* Presence of a disease or condition which is not preeclampsia * Drug or alcohol abuse during pregnancy * Obesity

Design outcomes

Primary

Measure	Time frame
Nitric oxide and Endothelin-1 levels	48 hours after tissue collection

Secondary

Measure	Time frame
Nitric oxide isoforms and Endothelin-1 receptor activation based on primary outcome	within 6 months from tissue collection

Countries

United States

Outcome results