Patients With SAT or LT After Stent Implantation (PCI)
Conditions
Keywords
in-stent-thrombosis, CD39, CD73, EPC
Brief summary
In-Stent-Thrombosis is a rare but serious complication after implantation of stents during PTCA.
Detailed description
In this prospective, open, not-randomized, controlled single-center pilot study 80 patients having had an in-stent-thrombosis (40 sub-acute thromboses (SAT), 40 late thromboses (LT)) and a control group of 80 patients having not developed a thrombosis will be compared. The aim of this study is the establishment of diagnostic markers vor prediction of SAT (detection of CD39- and CD73-activity, respectively)and of LT (EPC-number and function, respectively) correspondingly aiming at the early identification of patients with high risk for developing an in-stent-thrombosis.
Interventions
None listed
Sponsors
RWTH Aachen University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients having developed an SAT or LT after stent implantation using PTCA
Exclusion criteria
* instabel coronary heart diseases, * systemic autoimmune diseases, * rheumatic diseases, * tumors, * impaired kidney or liver function, * surgery within the last 3 months, * pregnant or lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The aim of this study is to establish diagnostic markers for prediction of SAT and LT, respectively, by identification of CD39 and CD73-activity and EPC-number and function, respectively. | may 08 to may 2010 |
Countries
Germany
Outcome results
None listed