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Pre-shock Cardiopulmonary Resuscitation to Patients With Out-of-hospital Resuscitation, A Randomised Clinical Trial

Does Longer Pre-shock Cardiopulmonary Resuscitation Improve the Outcome of Patients With Out-of-hospital Cardiac Arrest? A Randomized Control Trial.

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00650962
Acronym
CPR
Enrollment
1666
Registered
2008-04-02
Start date
2008-02-29
Completion date
2009-12-31
Last updated
2012-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Arrest

Keywords

CPR, Preshock CPR, OHCA, EMS

Brief summary

1. Pre-shock cardiopulmonary resuscitation might benefit the survival of out-of-hospital cardiac patients with ventricular fibrillation / ventricular tachycardia in a post-hoc analysis of a prehospital trial conducted in Europe (L.Wik,2002). However, it's effectiveness in the Asian countries, where most firstly recorded rhythm in out-of-hospital cardiac arrests patients were asystole/pulseless electric activity rather than ventricular fibrillation / ventricular tachycardia, were not explored yet. 2. This trial was designed to exam if pre-shock cardiopulmonary resuscitation by emergency medical technicians improves the outcome of all out-of-hospital cardiac arrest patients in an Asian metropolitan city.

Detailed description

1. Different from data from the Western countries, non-shockable rhythm (Asystole/pulseless electric activity) was responsible for most out-of-hospital cardiac arrest patients(80%\ 90%) in metropolitan Taipei. 2. Response time in Taipei emergency medical service was longer than 5 minutes. 3. Bystander cardiopulmonary resuscitation rate were relatively low in Taipei. 4. Cardiopulmonary resuscitation is the only known method to save out-of-hospital cardiac arrest patients with asystole/pulseless electric activity. For those suffered from ventricular fibrillation/ ventricular tachycardia,previous studies revealed pre-shock cardiopulmonary resuscitation may have the potential to improve the outcome. 5. Study hypothesis: Compared with current standard resuscitative sequence (basic life support protocol in Guideline 2005), longer pre-shock cardiopulmonary resuscitation provided to all out-of-hospital cardiac arrest patients in Taipei may improve the outcome of them.

Interventions

OTHERcardiopulmonary resuscitation

10 cycles of 30:2 cardiopulmonary resuscitation before rhythm analysis by AED

OTHERRhythm analysis

Rhythm analysis as soon as AED is ready

Sponsors

National Taiwan University Hospital
Lead SponsorOTHER
National Science and Technology Council, Taiwan
CollaboratorOTHER_GOV

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Patients with out-of-hospital cardiac arrest

Exclusion criteria

* Trauma * Age \< 18y/o * Airway obstruction * Submersion * Sign of obvious death * existing do not resuscitate (DNAR) order * family refusal * preceding CPR by BLS teams for longer than 2 minutes.

Design outcomes

Primary

MeasureTime frame
Sustained ROSC >= 2 hours180 days

Secondary

MeasureTime frame
surival to ICU admission180 days
survival to hospital discharge180 days
Rates of good neurology recovery (CPC 1 &2)180 days

Countries

Taiwan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026