Photoaging
Conditions
Brief summary
The primary purpose of this study is to compare the efficacy of adapalene (Differin®) gel 0.3% and tretinoin 0.05% emollient cream for the treatment of signs of photodamage, with tolerability assessment as a secondary objective.
Detailed description
Same as above.
Interventions
applied topically once daily in the evening
DRUGtretinoin 0.05% emollient cream
applied topically once daily in the evening
Sponsors
Galderma R&D
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Male or Female aged 40 years of age and older with Fitzpatrick skin types I through III * Clinically moderate to severe photodamage
Exclusion criteria
* Subjects with history of laser resurfacing, dermabrasion, medium or deep chemical peel of the face * Subjects with diagnosis of skin cancer within 3 months of study entry * Subjects who have had superficial chemical peels, exfoliation or microdermabrasion of the face within 3 months of study entry * Subjects who have had botulinum toxin for facial rejuvenation within 6 months of study entry and are unwilling to refrain from botulinum toxin treatments during the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change From Baseline in Overall Integrated Assessment of Photodamage at Week 24 | baseline to week 24 | Number of participants who improved (a decrease by at least one point) in Overall Integrated Assessment of Photodamage from baseline to week 24. Overall Integrated Assessment of Photodamage is a scale from 0 - 5 (0 = None, 1 = Minimal, 2 = Mild, 3 - Moderate, 4 = Severe and 5 = Very Severe) with 0 being best and 5 being worst. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | baseline, week 12 and week 24 | Number of participants in each category of the Photonumeric Scale for the Assessment of Photodamage from baseline to week 12 and baseline to week 24. Photonumeric Scale consisted of 9 categories (Fine Wrinkling, Mottled Pigmentation, Irregular Depigmentation, Lentigines, Coarse Wrinkling, Elastosis, Tactile Roughness, Telangiectasia, and Actinic Keratosis. These were evaluated on a scale from 0 - 4 (0 = None, 1 = Minimal, 2 = Mild, 3 = Moderate and 4 = Severe) with 0 being best and 4 being worst. |
| Number of Participants Who Improved (a Decrease of at Least One Point) in Overall Integrated Assessment of Photodamage From Baseline to Week 12. | baseline to week 12 | Number of participants who improved in Overall Integrated Assessment of Photodamage from baseline to week 12. Overall Integrated Assessment of Photodamage was evaluated on a scale from 0 - 5 (0 = None, 1 = Minimal, 2 = Mild, 3 = Moderate 4 = Severe and 5 = Very Severe) with 0 being best and 5 being worst. |
| Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 12 and week 24 | Number of participants in each category of the Subject Evaluation of Improvement at week 12 and week 24. Subject Evaluation of Improvement was evaluated on a scale from 0 - 6 (0 = Complete Improvement, 1 = Almost (\ 90%) Improvement, 2 = Marked (\ 75%) Improvement, 3 = Moderate (\ 50%) Improvement, 4 = Slight (\ 25%) Improvement, 5 = No Change, 6 = Worse) with 0 being best and 6 being worst. |
| Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 12 and week 24 | Number of participants in each category of the Investigator Evaluation of Global Response (Improvement) at week 12 and week 24. Investigator Evaluation of Global Response (Improvement) is evaluated on a scale from 0 - 6 (0 = Complete Response, 1 = Almost Complete (\ 90%) Response, 2 = Marked (\ 75%) Response, 3 = Moderate (\ 50%) Response, 4 = Slight (\ 25%) Response, 5 = No Response and 6 = Worsening) with 0 being best and 6 being worst. |
Countries
United States
Participant flow
Recruitment details
Dates of recruitment period: First subject was enrolled on June 17, 2008 and the last subject was enrolled on July 24, 2009.
Pre-assignment details
Wash-out period at baseline: 2 wks topical alpha-hydroxy, glycolic, salicylic, lactic, & beta-hydroxy acids, topical vitamin A, ascorbic acid, vitamin E, corticosteroids on face; 4 wks systemic corticosteroids; 3 mos topical retinoids, superficial chemical peels/exfoliation/microdermabrasion; 6 mos botulinum toxin on the face; 1 yr oral retinoids.
Participants by arm
| Arm | Count |
|---|---|
| Differin® Gel, 0.3% adapalene gel 0.3% - apply once daily in the evening for 24 weeks | 15 |
| Tretinoin Emollient Cream Tretinoin Emollient Cream 0.05% - apply topically once daily in the evening for 24 weeks | 15 |
| Total | 30 |
Withdrawals & dropouts
| Period | Reason | FG000 | FG001 |
|---|---|---|---|
| Overall Study | Adverse Event | 0 | 1 |
| Overall Study | Lost to Follow-up | 1 | 0 |
| Overall Study | Protocol Violation | 0 | 1 |
| Overall Study | Surgery for pre-existing neck pain | 1 | 0 |
| Overall Study | Withdrawal by Subject | 1 | 0 |
Baseline characteristics
| Characteristic | Differin® Gel, 0.3% | Tretinoin Emollient Cream | Total |
|---|---|---|---|
| Age, Continuous | 60.9 years STANDARD_DEVIATION 11.37 | 61.3 years STANDARD_DEVIATION 9.58 | 61.1 years STANDARD_DEVIATION 10.33 |
| Sex: Female, Male Female | 10 Participants | 12 Participants | 22 Participants |
| Sex: Female, Male Male | 5 Participants | 3 Participants | 8 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk |
|---|---|---|
| deaths Total, all-cause mortality | — / — | — / — |
| other Total, other adverse events | 7 / 15 | 14 / 15 |
| serious Total, serious adverse events | 0 / 15 | 0 / 15 |
Outcome results
Primary
Change From Baseline in Overall Integrated Assessment of Photodamage at Week 24
Number of participants who improved (a decrease by at least one point) in Overall Integrated Assessment of Photodamage from baseline to week 24. Overall Integrated Assessment of Photodamage is a scale from 0 - 5 (0 = None, 1 = Minimal, 2 = Mild, 3 - Moderate, 4 = Severe and 5 = Very Severe) with 0 being best and 5 being worst.
Time frame: baseline to week 24
Population: ITT (Intent to Treat), LOCF (Last Observation Carried Forward)
| Arm | Measure | Value (NUMBER) |
|---|---|---|
| Differin® Gel, 0.3% | Change From Baseline in Overall Integrated Assessment of Photodamage at Week 24 | 6 participants |
| Tretinoin Emollient Cream | Change From Baseline in Overall Integrated Assessment of Photodamage at Week 24 | 10 participants |
Secondary
Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24
Number of participants in each category of the Investigator Evaluation of Global Response (Improvement) at week 12 and week 24. Investigator Evaluation of Global Response (Improvement) is evaluated on a scale from 0 - 6 (0 = Complete Response, 1 = Almost Complete (\ 90%) Response, 2 = Marked (\ 75%) Response, 3 = Moderate (\ 50%) Response, 4 = Slight (\ 25%) Response, 5 = No Response and 6 = Worsening) with 0 being best and 6 being worst.
Time frame: week 12 and week 24
Population: ITT (Intent to Treat), LOCF (Last Observation Carried Forward)
| Arm | Measure | Group | Value (NUMBER) |
|---|---|---|---|
| Differin® Gel, 0.3% | Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 12 Missing | 3 participants |
| Differin® Gel, 0.3% | Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 12 Moderate Response | 2 participants |
| Differin® Gel, 0.3% | Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 24 Complete Response | 0 participants |
| Differin® Gel, 0.3% | Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 12 Almost Complete Response | 0 participants |
| Differin® Gel, 0.3% | Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 24 Almost Complete Response | 0 participants |
| Differin® Gel, 0.3% | Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 12 Slight Response | 9 participants |
| Differin® Gel, 0.3% | Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 24 Marked Response | 2 participants |
| Differin® Gel, 0.3% | Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 12 Complete Response | 0 participants |
| Differin® Gel, 0.3% | Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 24 Moderate Response | 2 participants |
| Differin® Gel, 0.3% | Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 12 No Response | 1 participants |
| Differin® Gel, 0.3% | Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 24 No Response | 2 participants |
| Differin® Gel, 0.3% | Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 12 Marked Response | 0 participants |
| Differin® Gel, 0.3% | Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 24 Worsening | 0 participants |
| Differin® Gel, 0.3% | Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 12 Worsening | 0 participants |
| Differin® Gel, 0.3% | Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 24 Missing | 3 participants |
| Differin® Gel, 0.3% | Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 24 Slight Response | 6 participants |
| Tretinoin Emollient Cream | Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 24 Missing | 0 participants |
| Tretinoin Emollient Cream | Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 12 Complete Response | 0 participants |
| Tretinoin Emollient Cream | Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 12 Almost Complete Response | 0 participants |
| Tretinoin Emollient Cream | Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 12 Marked Response | 1 participants |
| Tretinoin Emollient Cream | Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 12 Moderate Response | 4 participants |
| Tretinoin Emollient Cream | Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 12 Slight Response | 6 participants |
| Tretinoin Emollient Cream | Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 12 No Response | 2 participants |
| Tretinoin Emollient Cream | Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 12 Worsening | 0 participants |
| Tretinoin Emollient Cream | Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 12 Missing | 2 participants |
| Tretinoin Emollient Cream | Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 24 Complete Response | 0 participants |
| Tretinoin Emollient Cream | Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 24 Almost Complete Response | 0 participants |
| Tretinoin Emollient Cream | Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 24 Marked Response | 0 participants |
| Tretinoin Emollient Cream | Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 24 Slight Response | 4 participants |
| Tretinoin Emollient Cream | Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 24 No Response | 3 participants |
| Tretinoin Emollient Cream | Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 24 Worsening | 0 participants |
| Tretinoin Emollient Cream | Number of Participants in Each Category of the Investigator Evaluation of Global Response (Improvement) at Week 12 and Week 24 | week 24 Moderate Response | 8 participants |
Secondary
Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24
Number of participants in each category of the Subject Evaluation of Improvement at week 12 and week 24. Subject Evaluation of Improvement was evaluated on a scale from 0 - 6 (0 = Complete Improvement, 1 = Almost (\ 90%) Improvement, 2 = Marked (\ 75%) Improvement, 3 = Moderate (\ 50%) Improvement, 4 = Slight (\ 25%) Improvement, 5 = No Change, 6 = Worse) with 0 being best and 6 being worst.
Time frame: week 12 and week 24
Population: ITT (Intent to Treat; LOCF (Last Observation Carried Forward)
| Arm | Measure | Group | Value (NUMBER) |
|---|---|---|---|
| Differin® Gel, 0.3% | Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 24 Moderate Improvement | 4 participants |
| Differin® Gel, 0.3% | Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 12 Moderate Improvement | 4 participants |
| Differin® Gel, 0.3% | Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 24 Missing | 3 participants |
| Differin® Gel, 0.3% | Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 12 Slight Improvement | 4 participants |
| Differin® Gel, 0.3% | Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 24 No Change | 0 participants |
| Differin® Gel, 0.3% | Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 12 No Change | 0 participants |
| Differin® Gel, 0.3% | Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 12 Complete Improvement | 0 participants |
| Differin® Gel, 0.3% | Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 12 Worse | 0 participants |
| Differin® Gel, 0.3% | Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 24 Slight Improvement | 3 participants |
| Differin® Gel, 0.3% | Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 12 Missing | 3 participants |
| Differin® Gel, 0.3% | Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 12 Almost Complete Improvement | 0 participants |
| Differin® Gel, 0.3% | Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 24 Complete Improvement | 0 participants |
| Differin® Gel, 0.3% | Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 24 Worse | 0 participants |
| Differin® Gel, 0.3% | Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 24 Almost Complete Improvement | 3 participants |
| Differin® Gel, 0.3% | Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 12 Marked Improvement | 4 participants |
| Differin® Gel, 0.3% | Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 24 Marked Improvement | 2 participants |
| Tretinoin Emollient Cream | Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 12 Marked Improvement | 2 participants |
| Tretinoin Emollient Cream | Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 24 Moderate Improvement | 4 participants |
| Tretinoin Emollient Cream | Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 24 Slight Improvement | 1 participants |
| Tretinoin Emollient Cream | Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 24 No Change | 5 participants |
| Tretinoin Emollient Cream | Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 24 Worse | 0 participants |
| Tretinoin Emollient Cream | Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 24 Missing | 0 participants |
| Tretinoin Emollient Cream | Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 12 Complete Improvement | 0 participants |
| Tretinoin Emollient Cream | Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 12 Almost Complete Improvement | 0 participants |
| Tretinoin Emollient Cream | Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 24 Marked Improvement | 4 participants |
| Tretinoin Emollient Cream | Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 12 Moderate Improvement | 5 participants |
| Tretinoin Emollient Cream | Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 12 Slight Improvement | 4 participants |
| Tretinoin Emollient Cream | Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 12 No Change | 2 participants |
| Tretinoin Emollient Cream | Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 12 Worse | 0 participants |
| Tretinoin Emollient Cream | Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 12 Missing | 2 participants |
| Tretinoin Emollient Cream | Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 24 Complete Improvement | 0 participants |
| Tretinoin Emollient Cream | Number of Participants in Each Category of the Subject Evaluation of Improvement at Week 12 and Week 24 | week 24 Almost Complete Improvement | 1 participants |
Secondary
Number of Participants Who Improved (a Decrease of at Least One Point) in Overall Integrated Assessment of Photodamage From Baseline to Week 12.
Number of participants who improved in Overall Integrated Assessment of Photodamage from baseline to week 12. Overall Integrated Assessment of Photodamage was evaluated on a scale from 0 - 5 (0 = None, 1 = Minimal, 2 = Mild, 3 = Moderate 4 = Severe and 5 = Very Severe) with 0 being best and 5 being worst.
Time frame: baseline to week 12
Population: ITT (Intent to Treat), LOCF (Last Observation Carried Forward)
| Arm | Measure | Value (NUMBER) |
|---|---|---|
| Differin® Gel, 0.3% | Number of Participants Who Improved (a Decrease of at Least One Point) in Overall Integrated Assessment of Photodamage From Baseline to Week 12. | 6 participants |
| Tretinoin Emollient Cream | Number of Participants Who Improved (a Decrease of at Least One Point) in Overall Integrated Assessment of Photodamage From Baseline to Week 12. | 4 participants |
Secondary
Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24
Number of participants in each category of the Photonumeric Scale for the Assessment of Photodamage from baseline to week 12 and baseline to week 24. Photonumeric Scale consisted of 9 categories (Fine Wrinkling, Mottled Pigmentation, Irregular Depigmentation, Lentigines, Coarse Wrinkling, Elastosis, Tactile Roughness, Telangiectasia, and Actinic Keratosis. These were evaluated on a scale from 0 - 4 (0 = None, 1 = Minimal, 2 = Mild, 3 = Moderate and 4 = Severe) with 0 being best and 4 being worst.
Time frame: baseline, week 12 and week 24
Population: ITT (Intent to Treat), LOCF (Last Observation Carried Forward)
| Arm | Measure | Group | Value (NUMBER) |
|---|---|---|---|
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Fine wrinkling baseline Mild (2) | 3 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Lentigines week 24 Severe (4) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Coarse wrinkling baseline Mild (2) | 10 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Elastosis week 12 Moderate (3) | 4 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Tactile Roughness baseline None (0) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Actinic keratosis week 24 Moderate (3) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Lentigines baseline None (0) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Lentigines baseline Minimal (1) | 2 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Lentigines baseline Mild (2) | 5 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Lentigines baseline Moderate (3) | 7 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Lentigines baseline Severe (4) | 1 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Lentigines week 12 None (0) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Lentigines week 12 Minimal (1) | 3 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Lentigines week 12 Mild (2) | 7 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Lentigines week 12 Moderate (3) | 5 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Lentigines week 12 Severe (4) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Lentigines week 24 None (0) | 1 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Lentigines week 24 Minimal (1) | 3 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Lentigines week 24 Mild (2) | 7 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Lentigines week 24 Moderate (3) | 4 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Coarse wrinkling baseline None (0) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Elastosis week 12 Minimal (1) | 1 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Elastosis week 12 Mild (2) | 9 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Elastosis week 12 Severe (4) | 1 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Elastosis week 24 None (0) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Elastosis week 24 Minimal (1) | 2 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Elastosis week 24 Mild (2) | 10 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Elastosis week 24 Moderate (3) | 3 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Elastosis week 24 Severe (4) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Tactile Roughness baseline Minimal (1) | 7 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Tactile Roughness baseline Mild (2) | 3 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Tactile Roughness baseline Moderate (3) | 4 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Tactile Roughness baseline Severe (4) | 1 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Tactile Roughness week 12 None (0) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Tactile Roughness week 12 Minimal (1) | 9 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Tactile Roughness week 12 Mild (2) | 5 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Tactile Roughness week 12 Moderate (3) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Tactile Roughness week 12 Severe (4) | 1 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Tactile Roughness week 24 None (0) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Tactile Roughness week 24 Minimal (1) | 10 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Tactile Roughness week 24 Mild (2) | 4 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Coarse wrinkling baseline Minimal (1) | 1 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Tactile Roughness week 24 Moderate (3) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Coarse wrinkling baseline Moderate (3) | 2 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Coarse wrinkling baseline Severe (4) | 2 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Coarse wrinkling week 12 None (0) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Coarse wrinkling week 12 Minimal (1) | 2 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Coarse wrinkling week 12 Mild (2) | 9 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Coarse wrinkling week 12 Moderate (3) | 2 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Coarse wrinkling week 12 Severe (4) | 2 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Coarse wrinkling week 24 None (0) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Coarse wrinkling week 24 Minimal (1) | 2 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Coarse wrinkling week 24 Mild (2) | 8 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Coarse wrinkling week 24 Moderate (3) | 3 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Coarse wrinkling week 24 Severe (4) | 2 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Elastosis baseline None (0) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Elastosis baseline Minimal (1) | 1 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Elastosis baseline Mild (2) | 7 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Elastosis baseline Moderate (3) | 6 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Elastosis baseline Severe (4) | 1 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Elastosis week 12 None (0) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Telangiectasia week 12 None (0) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Tactile Roughness week 24 Severe (4) | 1 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Telangiectasia baseline None (0) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Telangiectasia baseline Minimal (1) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Telangiectasia baseline Mild (2) | 6 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Telangiectasia baseline Moderate (3) | 9 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Telangiectasia baseline Severe (4) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Telangiectasia week 12 Minimal (1) | 2 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Telangiectasia week 12 Mild (2) | 4 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Telangiectasia week 12 Moderate (3) | 8 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Telangiectasia week 12 Severe (4) | 1 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Telangiectasia week 24 None (0) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Telangiectasia week 24 Minimal (1) | 3 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Telangiectasia week 24 Mild (2) | 4 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Telangiectasia week 24 Moderate (3) | 7 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Telangiectasia week 24 Severe (4) | 1 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Actinic keratosis baseline None (0) | 8 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Actinic keratosis baseline Minimal (1) | 5 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Actinic keratosis week 12 Moderate (3) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Actinic keratosis baseline Mild (2) | 1 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Actinic keratosis baseline Moderate (3) | 1 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Actinic keratosis baseline Severe (4) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Actinic keratosis week 12 None (0) | 9 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Actinic keratosis week 12 Minimal (1) | 5 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Actinic keratosis week 12 Mild (2) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Actinic keratosis week 12 Severe (4) | 1 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Actinic keratosis week 24 None (0) | 12 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Actinic keratosis week 24 Minimal (1) | 2 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Actinic keratosis week 24 Mild (2) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Actinic keratosis week 24 Severe (4) | 1 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Irregular depigmentation week 12 Minimal (1) | 6 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Irregular depigmentation week 12 Mild (2) | 6 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Irregular depigmentation week 12 Moderate (3) | 2 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Irregular depigmentation week 12 Severe (4) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Irregular depigmentation week 24 None (0) | 1 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Irregular depigmentation week 24 Minimal (1) | 7 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Irregular depigmentation week 24 Mild (2) | 5 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Irregular depigmentation week 24 Moderate (3) | 2 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Fine wrinkling baseline None (0) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Fine wrinkling baseline Minimal (1) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Irregular depigmentation week 24 Severe (4) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Fine wrinkling baseline Moderate (3) | 12 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Fine wrinkling baseline Severe (4) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Fine wrinkling week 12 None (0) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Fine wrinkling week 12 Minimal (1) | 1 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Fine wrinkling week 12 Mild (2) | 9 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Fine wrinkling week 12 Moderate (3) | 5 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Fine wrinkling week 12 Severe (4) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Fine wrinkling week 24 None (0) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Fine wrinkling week 24 Minimal (1) | 2 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Fine wrinkling week 24 Mild (2) | 8 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Fine wrinkling week 24 Moderate (3) | 5 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Fine wrinkling week 24 Severe (4) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Mottled pigmentation baseline None (0) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Mottled pigmentation baseline Minimal (1) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Mottled pigmentation baseline Mild (2) | 7 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Mottled pigmentation baseline Moderate (3) | 8 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Mottled pigmentation baseline Severe (4) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Mottled pigmentation week 12 None (0) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Mottled pigmentation week 12 Minimal (1) | 1 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Mottled pigmentation week 12 Mild (2) | 7 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Mottled pigmentation week 12 Moderate (3) | 6 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Mottled pigmentation week 12 Severe (4) | 1 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Mottled pigmentation week 24 None (0) | 1 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Mottled pigmentation week 24 Minimal (1) | 3 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Mottled pigmentation week 24 Mild (2) | 6 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Mottled pigmentation week 24 Moderate (3) | 4 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Mottled pigmentation week 24 Severe (4) | 1 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Irregular depigmentation baseline None (0) | 1 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Irregular depigmentation baseline Minimal (1) | 5 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Irregular depigmentation baseline Mild (2) | 6 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Irregular depigmentation baseline Moderate (3) | 3 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Irregular depigmentation baseline Severe (4) | 0 participants |
| Differin® Gel, 0.3% | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Irregular depigmentation week 12 None (0) | 1 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Mottled pigmentation week 24 Minimal (1) | 10 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Lentigines week 12 Severe (4) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Telangiectasia baseline Moderate (3) | 4 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Coarse wrinkling baseline None (0) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Fine wrinkling baseline Minimal (1) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Coarse wrinkling week 12 Minimal (1) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Elastosis baseline Minimal (1) | 1 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Telangiectasia baseline Severe (4) | 2 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Elastosis week 24 Minimal (1) | 3 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Mottled pigmentation baseline Moderate (3) | 2 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Actinic keratosis baseline Minimal (1) | 3 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Actinic keratosis week 12 Mild (2) | 2 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Actinic keratosis week 12 Moderate (3) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Actinic keratosis week 24 None (0) | 8 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Telangiectasia week 12 Minimal (1) | 4 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Actinic keratosis week 24 Moderate (3) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Fine wrinkling baseline Mild (2) | 2 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Lentigines baseline None (0) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Telangiectasia week 12 Mild (2) | 5 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Lentigines baseline Minimal (1) | 3 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Irregular depigmentation baseline Severe (4) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Lentigines baseline Mild (2) | 9 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Telangiectasia week 12 Moderate (3) | 5 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Lentigines baseline Moderate (3) | 2 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Fine wrinkling baseline Moderate (3) | 11 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Lentigines baseline Severe (4) | 1 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Telangiectasia week 12 Severe (4) | 1 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Lentigines week 12 None (0) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Mottled pigmentation baseline Severe (4) | 1 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Lentigines week 12 Minimal (1) | 5 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Telangiectasia week 24 None (0) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Lentigines week 12 Mild (2) | 9 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Fine wrinkling baseline Severe (4) | 2 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Lentigines week 12 Moderate (3) | 1 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Telangiectasia week 24 Minimal (1) | 5 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Mottled pigmentation week 24 Mild (2) | 4 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Lentigines week 24 None (0) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Telangiectasia week 24 Mild (2) | 3 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Lentigines week 24 Minimal (1) | 7 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Fine wrinkling week 12 None (0) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Lentigines week 24 Mild (2) | 7 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Telangiectasia week 24 Moderate (3) | 6 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Lentigines week 24 Moderate (3) | 1 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Lentigines week 24 Severe (4) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Mottled pigmentation week 12 None (0) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Telangiectasia week 24 Severe (4) | 1 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Elastosis week 12 Minimal (1) | 1 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Fine wrinkling week 12 Minimal (1) | 1 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Elastosis week 12 Mild (2) | 6 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Elastosis week 12 Moderate (3) | 7 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Actinic keratosis baseline None (0) | 9 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Elastosis week 12 Severe (4) | 1 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Irregular depigmentation baseline Minimal (1) | 7 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Elastosis week 24 None (0) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Fine wrinkling week 12 Mild (2) | 4 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Irregular depigmentation week 24 Severe (4) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Elastosis week 24 Mild (2) | 8 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Mottled pigmentation week 12 Minimal (1) | 7 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Elastosis week 24 Moderate (3) | 3 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Actinic keratosis baseline Mild (2) | 1 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Elastosis week 24 Severe (4) | 1 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Tactile Roughness baseline None (0) | 1 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Fine wrinkling week 12 Moderate (3) | 9 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Tactile Roughness baseline Minimal (1) | 4 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Actinic keratosis baseline Moderate (3) | 2 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Tactile Roughness baseline Mild (2) | 7 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Mottled pigmentation week 24 Moderate (3) | 1 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Tactile Roughness baseline Moderate (3) | 3 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Actinic keratosis baseline Severe (4) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Tactile Roughness baseline Severe (4) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Fine wrinkling week 12 Severe (4) | 1 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Tactile Roughness week 12 None (0) | 1 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Actinic keratosis week 12 None (0) | 9 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Tactile Roughness week 12 Minimal (1) | 6 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Mottled pigmentation week 12 Mild (2) | 5 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Tactile Roughness week 12 Mild (2) | 7 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Actinic keratosis week 12 Minimal (1) | 4 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Tactile Roughness week 12 Moderate (3) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Fine wrinkling week 24 None (0) | 1 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Tactile Roughness week 12 Severe (4) | 1 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Irregular depigmentation baseline Moderate (3) | 2 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Tactile Roughness week 24 None (0) | 1 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Actinic keratosis week 12 Severe (4) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Tactile Roughness week 24 Minimal (1) | 11 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Fine wrinkling week 24 Minimal (1) | 2 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Tactile Roughness week 24 Mild (2) | 3 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Mottled pigmentation week 12 Moderate (3) | 3 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Actinic keratosis week 24 Minimal (1) | 5 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Coarse wrinkling baseline Minimal (1) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Coarse wrinkling baseline Mild (2) | 5 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Fine wrinkling week 24 Mild (2) | 4 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Coarse wrinkling baseline Moderate (3) | 7 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Actinic keratosis week 24 Mild (2) | 2 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Coarse wrinkling baseline Severe (4) | 3 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Mottled pigmentation week 24 Severe (4) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Coarse wrinkling week 12 None (0) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Actinic keratosis week 24 Severe (4) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Irregular depigmentation week 12 None (0) | 1 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Coarse wrinkling week 12 Mild (2) | 8 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Fine wrinkling week 24 Moderate (3) | 7 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Coarse wrinkling week 12 Moderate (3) | 4 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Irregular depigmentation week 12 Minimal (1) | 9 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Coarse wrinkling week 12 Severe (4) | 3 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Mottled pigmentation week 12 Severe (4) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Coarse wrinkling week 24 None (0) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Irregular depigmentation week 12 Mild (2) | 4 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Coarse wrinkling week 24 Minimal (1) | 2 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Fine wrinkling week 24 Severe (4) | 1 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Coarse wrinkling week 24 Mild (2) | 6 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Irregular depigmentation week 12 Moderate (3) | 1 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Coarse wrinkling week 24 Moderate (3) | 4 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Irregular depigmentation baseline Mild (2) | 5 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Coarse wrinkling week 24 Severe (4) | 3 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Irregular depigmentation week 12 Severe (4) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Elastosis baseline None (0) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Mottled pigmentation baseline None (0) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Irregular depigmentation week 24 None (0) | 1 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Elastosis baseline Mild (2) | 5 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Mottled pigmentation week 24 None (0) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Elastosis baseline Moderate (3) | 8 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Irregular depigmentation week 24 Minimal (1) | 9 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Elastosis baseline Severe (4) | 1 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Mottled pigmentation baseline Minimal (1) | 4 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Elastosis week 12 None (0) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Irregular depigmentation week 24 Mild (2) | 5 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Tactile Roughness week 24 Moderate (3) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Irregular depigmentation baseline None (0) | 1 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Tactile Roughness week 24 Severe (4) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Irregular depigmentation week 24 Moderate (3) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Telangiectasia baseline None (0) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Mottled pigmentation baseline Mild (2) | 8 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Telangiectasia baseline Minimal (1) | 4 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Fine wrinkling baseline None (0) | 0 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Telangiectasia baseline Mild (2) | 5 participants |
| Tretinoin Emollient Cream | Photonumeric Scale for the Assessment of Photodamage From Baseline to Week 12 and Baseline to Week 24 | Telangiectasia week 12 None (0) | 0 participants |