Intractable Epilepsy
Conditions
Keywords
Intractable epilepsy, Drug Reduction, Antiepileptic medication
Brief summary
The primary aim of the study is to determine the effect of reducing the number and/or dose of anti epileptic drugs on an individual's quality of life and seizure control in people with difficult to control epilepsy and who are on polytherapy. This is a randomised trial so children will be divided into two groups, with reduction of anti epileptic drugs in the first group (withdrawal group) and no change to their medications in the second (control group). Irrespective of the group the child is assigned to (withdrawal group or control group), we will ask parents to complete several questionnaires on 2 occasions: the first time will be immediately after the child enters the study (i.e. baseline assessment), and a second and last one will be 6 months after entering the study (i.e. follow-up assessment). These questionnaires aim to quantify aspects related with quality of life, AED side effects, seizure severity, and behaviour.
Interventions
OTHERReduction of anti-epileptic medications
Reduction in anti-epileptic medications
PROCEDURENo drug change
No change in anti-epileptic treatment
Sponsors
Institute of Child Health
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
6 Years to 21 Years
Healthy volunteers
No
Inclusion criteria
* Young people aged 6-21 years with intractable epilepsy receiving antiepileptic drug polytherapy
Exclusion criteria
* None
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effect of reduction in anti-epileptic medications on quality of life in young people with intractable epilepsy | 6 months |
Secondary
| Measure | Time frame |
|---|---|
| Identify other determinants of quality of life in this group of subjects | 6 months |
Countries
United Kingdom
Contacts
Primary ContactDr R Scott, Phd
Outcome results
None listed